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Role of Occupational Neurotoxicants in Psychiatric and Neurodegenerative Disorders
Published in Lucio G. Costa, Luigi Manzo, Occupatinal Neurotoxicology, 2020
Stefano M. Candura, Luigi Manzo, Lucio G. Costa
The neurotoxic effect of manganese (Mn) has been known for a long time. In 1837, only 20 years after James Parkinson published his “Essay on the Shaking Palsy,” a syndrome similar to PD was described in five subjects who worked in a Mn ore-crushing plant.110 Manganism has since been noted in hundreds of cases, particularly in miners, smelters, and workers involved in the manufacture of dry batteries.91,111 The disorder starts gradually with nonspecific symptoms, often of a psychiatric nature (“manganese madness” or “locura manganica”), such as hallucinations, emotional lability, and compulsive and aberrant behavior. In a following stage, motor disturbances (generalized bradykinesia, rigidity, muscular weakness, clumsiness, impaired speech) somewhat similar to those of PD appear. Patients can also develop the motor deficits of manganism without having experienced any phase of manganese madness.111,112
Metals in the workplace
Published in Sue Reed, Dino Pisaniello, Geza Benke, Kerrie Burton, Principles of Occupational Health & Hygiene, 2020
Manganese is an essential trace element, but in excessive amounts it can cause neurological disorders involving the central nervous system. Symptoms of manganism range from apathy, anorexia and mental excitement to speech disturbance, clumsiness and a stone-faced appearance. In the established phase of the disease, staggering gait, muscular rigidity (e.g. finger or hand deformation), spasmodic laughter or tremors may occur. Manganese-poisoning victims may be cripplingly debilitated but otherwise well. There was concern by some that MMT might contribute to neurological effects similar to those caused by tetraethyl lead in petrol, but this has not eventuated.
Metals in the workplace
Published in Sue Reed, Dino Pisaniello, Geza Benke, Principles of Occupational Health & Hygiene, 2020
Manganese is an essential trace element, but in excessive amounts it can cause neurological disorders involving the central nervous system. Symptoms of manganism range from apathy, anorexia and mental excitement to speech disturbance, clumsiness and a stone-faced appearance. In the established phase of the disease, staggering gait, muscular rigidity (e.g. finger or hand deformation), spasmodic laughter or tremors may occur. Manganese-poisoning victims may be cripplingly debilitated but otherwise well. There was concern by some that MMT might contribute to neurological effects similar to those caused by tetraethyl lead in petrol, but this has not eventuated.
Column adsorption study for the removal of chromium and manganese ions from electroplating wastewater using cashew nutshell adsorbent
Published in Cogent Engineering, 2020
M. D. Yahya, A. S. Aliyu, K. S. Obayomi, A. G. Olugbenga, U. B. Abdullahi
Manganese is an essential metal ion for normal physiological functioning of human beings and animals. Exposure to low levels in the diet is nutritionally beneficial to healthy human life; however, chronic exposure to higher doses is detrimental to human health. It is toxic and its toxicity varies with route of exposure, chemical species, age, sex, and animal species (Kohl & Medlar, 2007). Syndrome called “manganism” result from chronic exposure to higher dosage and it is characterized by weakness, tremors, a mask-like face, and psychological disturbance among other symptoms (Dandang et al., 2017).