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Phenolic Compounds potential health Benefits and toxicity
Published in Quan V. Vuong, Utilisation of Bioactive Compounds from Agricultural and Food Waste, 2017
Deep Jyoti Bhuyan, Amrita Basu
Another dietary flavonoid—keamferol (also known as kaempferol), a type of phytoestrogen found in a number of fruits and vegetables—is shown to promote human health by reducing the risk of chronic diseases, especially cancer (Chen 2013, Kim and Choi 2013, Lee and Kim 2016). It is reported to regulate major elements of cellular signal transduction pathways associated with apoptosis, angiogenesis, inflammation and metastasis (Zhang et al. 2008, Chen and Chen 2013, Lee and Kim 2016). The anticancer effect of kaempferol in MIA PaCa-2, PANC-1, and SNU-213 human pancreatic cancer cells is mediated by inhibition of EGFR related Src, ERK1/2, and AKT pathways (Lee and Kim 2016). Furthermore, kaemferol is reported to inhibit the migration and invasion ability of medulloblastoma (Labbe et al. 2009) and breast cancer cells (Phromnoi et al. 2009).
Antioxidant and cytoprotective effects of avocado oil and extract (Persea americana Mill) against rotenone using monkey kidney epithelial cells (Vero)
Published in Journal of Toxicology and Environmental Health, Part A, 2021
Nelzi Ferreira Queiroz Junior, Jovani Antônio Steffani, Larissa Machado, Pâmela Jéssyca Hoss Longhi, Marco Aurélio Echart Montano, Mathias Martins, Sérgio Abreu Machado, Alencar Kolinski Machado, Francine Carla Cadoná
The antioxidant effects of avocado that found in our study may be attributed to the important chemical matrix present in this natural product (Mardigan et al. 2019). Avocado also contains some bioactive compounds that display antioxidant and anti-inflammatory actions including apigenin, catechins (especially epigallocatechin gallate – EGCG), and kaempferol (Patel, Shukla, and Gupta 2007; Tang et al. 2017). Ingestion of apigenin is a natural flavone was reported to reduce the risk of chronic diseases such as cancer (Salehi et al. 2019; Sharma et al. 2019). Among catechins, EGCG is considered a molecule with significant antioxidant and anti-inflammatory action (Garcia-Rodriguez et al. 2021). Kaempferol, being also a flavone, has several medicinal proprieties already established, such as antioxidant, antidiabetic, anti-inflammatory, and anticancer (Imran et al. 2019; Wang et al. 2018a, 2018b; Wu et al. 2018).