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Disease-Inspired Feature Design for Computer-Aided Diagnosis of Breast Cancer Digital Pathology Images
Published in de Azevedo-Marques Paulo Mazzoncini, Mencattini Arianna, Salmeri Marcello, Rangayyan Rangaraj M., Medical Image Analysis and Informatics: Computer-Aided Diagnosis and Therapy, 2018
More commonly used staining protocols, in all types of cancers and tissue analysis, include those that employ the H&E stains. Instead of considering specific proteins or biomarkers, H&E stains make visible the structural characteristics of cells and tissue [13]. Hematoxylin is a bluish (or purple) stain that has an affinity to acidic structures like nucleic acids (nuclei). Eosin usually has an affinity to th e background stroma and is generally colored pink.
Evaluation of statistical and Haralick texture features for lymphoma histological images classification
Published in Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 2021
Thaína A. Azevedo Tosta, Paulo R. de Faria, Leandro A. Neves, Marcelo Z. do Nascimento
Lymphoma diagnosis is performed through microscopic analysis of histological samples (Orlov et al. 2010). These samples are prepared by different steps, as the sectioning, staining, and digitisation. These steps can lead to variation of appearance of the lymphoma tissues, making the diagnoses harder (Khan et al. 2014; Li and Plataniotis 2015). For the different histological structures can be identified, the haematoxylin-eosin (H&E) stain is commonly used. The haematoxylin dye stains acid regions in purple shades, like cell nuclei, and basics regions are stained in pink by the eosin (Bilgin et al. 2012). The digitisation of these samples generates the so-called histological images, that allow the application of image processing techniques to aid in diagnoses.