Demethylase

Demethylase

Emerging Risks and Final Thoughts

Published in Ted W. Simon, Environmental Risk Assessment, 2019

Epigenetics also plays a role in the acquisition of the hallmarks of cancer during malignant transformation. Tumor cells often display alterations in DNA methylation patterns and dysregulated developmental programs. These epigenetic changes may represent the biological underpinnings of the hallmarks. For example, histone lysine demethylase enzymes remove methyl groups from the histone proteins and may foster the transcription of cancer-associated genes.

Epigenotoxicity: a danger to the future life

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Journal Information

Published in Journal of Environmental Science and Health, Part A, 2023

Farzaneh Kefayati, Atoosa Karimi Babaahmadi, Taraneh Mousavi, Mahshid Hodjat, Mohammad Abdollahi

This reaction occurs by increasing the methyl group to arginine and lysine amino acids. The enzyme used for that reaction is methyltransferase, a reversible and continuous reaction since cell division increases this chemical reaction.[15] Demethylase catalyzes and removes methyl groups, contrary to methyltransferase activity. This has the opposite effect on the epigenetic regulation of genes. What remains of lysines can be mono-, di- or tri-methylated. Histone methylation is related to the silencing and activation of gene expression.[16]

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Emerging Risks and Final Thoughts

Epigenotoxicity: a danger to the future life