Cytidine monophosphate

Cytidine monophosphate (CMP) is a nucleotide that is also known as 5’-cytidylic acid or cytidylate (C9H14N3O8P). It is synthesized through the activation of Neu5Ac (or Sia) to the cytidine monophosphate diester (CMP-Neu5Ac or CMP-Sia) by the CMP-sialic acid synthetase (CSS) in the nucleus. CMP is also involved in the transfer of phosphocholine from cytidine diphosphate (CDP)-choline to generate PC and CMP, which is catalyzed by CDP-choline: 1,2-diacylglycerol cholinephosphotransferase (CPT, E.C. 2.7.8.2).From: Scientific and Technical Terms in Bioengineering and Biological Engineering [2018], Carbohydrate-Modifying Biocatalysts [2019], Lipid Biotechnology [2018]

Glossary of scientific and technical terms in bioengineering and biological engineering

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Published in Megh R. Goyal, Scientific and Technical Terms in Bioengineering and Biological Engineering, 2018

Megh R. Goyal

CMP is an abbreviation for cytidine monophosphate, that is also known as also known as 5’-cytidylic acid or simply cytidylate (C9H14N3O8P). CMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase cytosine.

Assembly of nucleobases into rings and cages via metal ions

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Published in Journal of Coordination Chemistry, 2022

Bernhard Lippert, Pablo J. Sanz Miguel

An alternative to intramolecular chelation of a metal ion by a nucleotide, which provides the mentioned macrochelate, is intermolecular metal binding, leading to a dinuclear complex. [Pt(en)(5′-CMP)]2 (with 5′-CMP = 5′-cytidine monophosphate) [17] is a typical example. In it, both PtII ions bind to N3 of the cytosine and an oxygen of the phosphate group each, thereby producing a head-tail dinuclear species. There is even the possibility of having exclusive metal binding to two bridging phosphate groups, with the nucleobases not involved in metal binding at all, such as in [Cu(L)(H2O)(5′-UMP)]2 [17] (with L = o-phenanthroline and 5′-UMP = 5′-uridine monophosphate), but of course, this pattern is phosphate—rather than nucleobase—specific. Related to this pattern are dinuclear nucleobase complexes with other bridging ligands such as hydroxide [18] or halide [19], and terminal nucleobases, which we likewise will not discuss further. The more typical 2:2-complexes are those, in which both metal ions cross-link donor sites of the heterocyclic rings. Examples today include virtually all common nucleobases.

Cytidine monophosphate

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Glossary of scientific and technical terms in bioengineering and biological engineering

Assembly of nucleobases into rings and cages via metal ions