Copalic acid

Copalic acid

A Brief History of Terpenoids

Published in Dijendra Nath Roy, Terpenoids Against Human Diseases, 2019

Milena Campelo Freitas de Lima, Larissa Sousa da Silva, Larissa Silveira Moreira Wiedemann, Valdir F. da Veiga

Copalic acid (ent-8-(17)-13E-labdadien-15-oic) is a biomarker from copaiba oils (Copaifera sp.), a diterpene observed in all species but mainly in Copaifera multijuga Hayne (da Veiga Jr. et al., 1997; Cascon and Gilbert, 2000). It was first isolated from another Brazilian oil resin, named Brazilian Copal (Hymenaea courbail L.), in 1961, by Carl Djerassi (Nakano and Djerassi, 1961).

Antigenotoxicity properties of Copaifera multijuga oleoresin and its chemical marker, the diterpene (−)-copalic acid

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Journal Information

Published in Journal of Toxicology and Environmental Health, Part A, 2018

Jacqueline Morais Alves, Luís Fernando Leandro, Juliana Marques Senedese, Pâmela Tinti de Castro, Daiane Eleutério Pereira, Flávia Aparecida Resende, Débora Leite Campos, Jonas Joaquim Mangabeira da Silva, Eliana Aparecida Varanda, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Denise Crispim Tavares

Comparing the in vivo and in vitro results obtained for CMO and CA, data suggest that the diterpene is partially responsible for the antigenotoxic effect attributed to oleoresin. The antigenotoxic activity demonstrated in the treatment with the concentrations of CMO was also detected in the corresponding concentrations of CA. (−)-Copalic acid is the most abundant diterpene in CMO (Veiga et al. 2007).

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A Brief History of Terpenoids

Antigenotoxicity properties of Copaifera multijuga oleoresin and its chemical marker, the diterpene (−)-copalic acid