Claisen condensation

Enolate Anions and Condensation Reactions

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Published in Michael B. Smith, A Q&A Approach to Organic Chemistry, 2020

Michael B. Smith

This reaction is called the Claisen condensation. What is a Claisen self-condensation?

An efficient, one-pot, regioselective synthesis of 2-aryl/hetaryl-4-methyl-5-acylthiazoles under solvent-free conditions

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Published in Journal of Sulfur Chemistry, 2022

Ranjana Aggarwal, Mona Hooda, Naman Jain, Dionisia Sanz, Rosa M. Claramunt, Brendan Twamley, Isabel Rozas

Starting materials were synthesized following published methods; thus, thiobenzamide (1a) was prepared by sulfurization of benzamide with Lawesson’s reagent [44] substituted thioamides (1b-d) were obtained from corresponding carboxylic acids following reported methods [45] and unsymmetrical β-diketones (5a-h) were prepared in good yields by conventional Claisen condensation involving reaction of enolisable ketones with ethyl acetate in the presence of sodium ethoxide [46].

Chalconoid metal chelates: spectral, biological and catalytic applications

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Published in Journal of Coordination Chemistry, 2019

Jino Johnson, A. Yardily

Replacement of the phenyl ring with a cyclopentadienyl group results in formation of “piano tool”-type complexes [CpM(CO)3] (M = Re or Tc) (see 18, Scheme 3) [52]. Rhenium complexes were prepared by acetylation of [CpRe(CO)3] using acetyl chloride. Then the base catalyzed Claisen condensation with aldehyde affords the chalcone-cyclopentadienyl complex. The class of ferrocenyl-chalcones has been discussed in many reviews [53–58].

Claisen condensation

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Enolate Anions and Condensation Reactions

An efficient, one-pot, regioselective synthesis of 2-aryl/hetaryl-4-methyl-5-acylthiazoles under solvent-free conditions

Chalconoid metal chelates: spectral, biological and catalytic applications