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Inflammatory Biomarkers: An Important Tool for Herbal Drug Discovery
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mahfoozur Rahman, Ankit Sahoo, Mohammad Atif, Sarwar Beg
Celastrol is pentacyclic triterpene obtained and used in Chinese traditional medicine. It has anti-tumor and anti-inflammatory properties. During the daily administration to AIA rats of celastrol I.P administration, shows anti-inflammatory action possibly through the inhibition of caspase-1 and inhibits the activation of NF-JB, and downregulation of the IL-lb and TNF secretion in an AIA rat model.
Terpenoids in Treatment of Neurodegenerative Disease
Published in Dijendra Nath Roy, Terpenoids Against Human Diseases, 2019
Celastrol is a triterpene compound obtained from Tripterygium wilfordii (an ivy-like vine). Celastrol treatment diminishes dopaminergic neuronal loss and suppresses DOPAC and DA level depletion in MPTP induced mice (Cleren et al., 2005).
Topical application of celastrol alleviates atopic dermatitis symptoms mediated through the regulation of thymic stromal lymphopoietin and group 2 innate lymphoid cells
Published in Journal of Toxicology and Environmental Health, Part A, 2021
Jae Kwon Lee, Jin Kyung Seok, Ilyoung Cho, Gabsik Yang, Kyu-Bong Kim, Seung Jun Kwack, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Since current medicines do not provide effective fundamental treatment for atopic dermatitis, development of new strategies to overcome the limitations is required (Choi et al. 2020). Since there have been an extensive effort to identify natural products protecting from toxicant-induced stress and pathological symptoms (Sbardelotto et al. 2021; Seok et al. 2021), we intended to find a novel natural compound for preventing inflammatory responses of atopic dermatitis. Celastrol is a pentacyclic triterpenoid belonging to quinone methides compound isolated from Trypterygium Wilfordii Hook. Celastrol exerts anti-inflammatory and anti-cancer effects in several disease models including Alzheimer’s disease, arthritis, asthma, and cancer metastasis (Allison et al. 2001; Lee et al. 2019; Wong et al. 2019b). Celastrol suppressed airway inflammation in allergic asthma mouse models and exerted anti-allergic effects by targeting mast cells and basophils (Kim et al. 2009). However, the effects of celastrol on TSLP expression levels and atopic dermatitis symptoms have not yet been elucidated. The aim of this study was to determine whether topical application of celastrol might improve atopic dermatitis symptoms by altering TSLP expression levels and subsequent immune responses.