Bromodichloromethane

Bromodichloromethane is a disinfection by-product formed during the chlorination of drinking water containing natural organic matter. It is one of the four trihalomethanes formed, along with chloroform, dibromochloromethane, and bromoform. There is evidence that bromodichloromethane is carcinogenic in experimental animals and is classified as a probable human kidney carcinogen.From: Species-specific interaction of trihalomethane (THM) precursors in a scaled-up distribution network using response surface methodology (RSM) [2018], and Safety [2016], Risk assessment of volatile organic compounds (VOCs) detected in sanitary pads [2019]

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Published in T.S.S. Dikshith, and Safety, 2016

T.S.S. Dikshith

There is sufficient evidence for the carcinogenicity of bromodichloromethane in experimental animals, but the evidence is inadequate in humans. The IARC has classified bro-modichloromethane as Group 2B, meaning a possible human carcinogen.

Risk assessment of volatile organic compounds (VOCs) detected in sanitary pads

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Published in Journal of Toxicology and Environmental Health, Part A, 2019

Hyang Yeon Kim, Jung Dae Lee, Ji-Young Kim, Joo Young Lee, Ok-Nam Bae, Yong-Kyu Choi, Eunji Baek, Sejin Kang, Chungsik Min, Kyungwon Seo, Kihwan Choi, Byung-Mu Lee, Kyu-Bong Kim

The oral slope factors for 5 of the 15 carcinogenic VOCs are presented in Table 5. 1,2-Dichloropropane (5.62E-7) exhibited highest cancer risk to induce liver cancer in mice, but did not undergo a complete evaluation under the US EPA’s IRIS program for evidence of human carcinogenic potential (EPA 1997b). Bromodichloromethane is classified as a probable human kidney carcinogen. In an animal study (B6C3F1 mice, male), multiple tissue tumors were observed (EPA 1987a). Carbon tetrachloride produces liver cancer in rats, mice, and hamsters. However, values for carcinogenicity by the oral route were insufficient to derive a quantitative estimate of cancer risk (EPA 2010b). 1,2-Dichloroethane is indicated as a possible human carcinogen (angiosarcoma) from inhalation or oral exposure (EPA 1987c). The oral exposure is dose-dependent but the oral slope factor is higher than that of the other four VOCs. 1,4-Dichlorobenzene is classified only by the IARC as an animal carcinogen inducing liver cancer (EPA 1997b).

Bromodichloromethane

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Risk assessment of volatile organic compounds (VOCs) detected in sanitary pads