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Biorecognition Elements in Biosensors
Published in Sibel A. Ozkan, Bengi Uslu, Mustafa Kemal Sezgintürk, Biosensors, 2023
Michael López Mujica, Alejandro Tamborelli, Virginia Vaschetti, Pablo Gallay, Fabrizio Perrachione, Daiana Reartes, Rocío Delpino, Marcela Rodríguez, María D. Rubianes, Pablo Dalmasso, Gustavo Rivas
Biosensors have received great interest in the field of modern bioanalysis due to the high demand and opportunities that are emerging especially in diagnostics, food, drugs, environmental analysis, and quality and safety control. Even after six decades from the first enzymatic biosensor, enzymes still attract enormous attention. However, the successful use of antibodies for preparing immunosensors has made them the workhorse for the development of biosensing platforms able to quantify each new biomarker/bioanalyte of relevance. In spite of this preference for antibodies-based biosensors, new synthetic molecules that mimic natural biorecognition processes have been demonstrated to be extremely useful for the design of bioplatforms due to the multiple advantages that they present, mainly connected with the possibility of large scale production, robustness, and stability. In addition, their easy chemical modification gives them enormous possibilities to design new immobilization strategies and to build novel supramolecular architectures with biosensing applications. Surely, the future of the biorecognition event will be closely connected with the possible massive production of nanobodies, the use of new lectins and cell receptors, and the possibility of synthesizing new molecules analogues to biomolecules.
Analysis of heat transfer and thin film flow of
Published in Numerical Heat Transfer, Part A: Applications, 2023
The most noble among the family of metallic nanoparticles are gold nanoparticles. Different gold nanoparticle shapes include cylinders, nanorods, spheres, triangles, and more. In biomedical applications like medication, medical treatment, and diagnosis, gold nanoparticles are helpful. Gold nanoparticles containing DNA have been used extensively in bioanalysis and medicine. Due to its outstanding properties, AU-DNA are leading tools for medication delivery. A novel and intriguing method for creating genetic biosensors is the use of gold nanoparticles with DNA. In this study, Srinivas et al. [23], considered blood containing gold nanoparticles for its flow and heat transmission properties in a porous channel. The base fluid, blood, is regarded as Newtonian fluid, and the nanoparticles are gold The stability analysis of a hybrid nanofluid over a nonlinear shrinking sheet was explored in this research by Lund et al. [24]. were the main components of the hybrid nanomaterials. hybrid nanofluid was created by dissolving these hybridized nanomaterials in water, which was used as the basis fluid. In this article, Mekheimer et al. [25] investigated the impact of heat transfer with blood flow in a space between two coaxial tubes that contains gold nanoparticles using a non-Newtonian model.
A magnetophoretic microdevice for multi-magnetic particles separation based on size: a numerical simulation study
Published in Engineering Applications of Computational Fluid Mechanics, 2022
Jia Ruan, Weiwei Zhang, Chi Zhang, Na Li, Jian Jiang, Huilan Su
In recent years, the application of magnetic particles as magnetic carriers and adsorbents on medical diagnosis, bioanalysis, or therapy (drug delivery, cell separation, bacterial and viral detection, DNA isolation, protein purification, and rare cancer cell detection, etc.) has become very popular owing to its good biocompatibility, chemical stability, high loading capacity, mild operating conditions and low cost (Shasha & Krishnan, 2021). Sorting different magnetic particles from each other based on size can help target biomolecules or cells separate from the complex solution and enhance bioanalytical efficiency distinctly.
Microwave-assisted synthesis of rhodamine derivatives
Published in Green Chemistry Letters and Reviews, 2018
Fasil Abebe, Treshaun Sutton, Pierce Perkins, Khalil Makins-Dennis, Angela Winstead
It has been known for many years that the rhodamine compounds are widely used class of dyes due to their versatile applications in various fields (1, 2). In particular, rhodamine dyes see the widespread application as fluorescent sensors. Because of their strong fluorescence and good photostability, rhodamine derivatives have been found to have applications in laser active media (3), fluorescent markers in biology (4), imaging and bioanalysis (5), DNA sequencing (6) and fluorescence switchers and sensors (7–10).