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Marine Algae in Diabetes and Its Complications
Published in Se-Kwon Kim, Marine Biochemistry, 2023
The phlorotannins such as phlorofucofuroeckol-A (IC50 2.4 × 103 μM), eckol (IC50 1.6 × 103 μM), phloroglucinol (IC50 2.4 × 103 μM), fucofuroeckol A (IC50 7.4 × 102 μM), dieckol (IC50 7.4 × 102 μM), and 8,8′-bieckol (IC50 6.9 × 102 μM) isolated from E. cava have been reported to exhibit a potent inhibitory effect on the formation of fluorescence-bound advanced glycation end products (AGEs) compared to the reference drug aminoguanidine hydrochloride (IC50 8.1 × 103 μM) (Sugiura et al., 2017). Phlorotannins in the methanol extract of brown algae Padina pavonica, Sargassum polycystum, and Turbinaria ornata inhibited glucose-induced protein glycation and formation of protein-bound fluorescent AGEs. The results revealed that the phlorotannins present in P. pavonica have a potent ability to inhibit the formation of AGEs (IC50 15.16 ± 0.26 μg/ml) than S. polycystum (IC50 35.245 ± 2.3 μg/ml) and T. ornata (IC50 22.7 ± 0.3 μg/ml) compared to the standard thiamine (IC50 263 μg/ml) and phloroglucinol (IC50 222.33 μg/ml). In addition, further in vivo studies confirmed the hypoglycemic effect of phlorotannins present in brown algae P. pavonica, S. polycystum, and T. ornate, which exhibited inhibitory activity on the formation of AGEs in Caenorhabditis elegans (a nematode) with induced hyperglycamia (Shakambari et al., 2015).
A two-step strategy to synthesis new aminoguanidinium complexes: cytotoxic effect and perspectives
Published in Inorganic and Nano-Metal Chemistry, 2022
Natarajan Arunadevi, Ponnusamy Kanchana, Venkatesan Hemapriya, Mayilsamy Mehala, Manoharan Swathika, Ill-Min Chung, Mayakrishnan Prabakaran
Cytotoxicity studies of aminoguanidine tetrahydropyran derivatives show excellent activity against HT-29, K563, MCF-7, L929, PBMC, and PBMCLMC cancer cell lines. Aminoguanidine on pancreatic cancer cells, reduces the tumoral activity associated with the decreased proliferation of tumor cells, reduced angiogenesis and expression of antioxidant enzyme.[35–37] For treatment of cancer, platinum (II) complexes are predominantly used. Cisplatin, a platinum complex is the highly used anticancer drug for treating cancers in breast, lungs, pancreas, colon, cervical, neck, and bladder. Some cadmium metal complexes like cadmium/sodium-cadmium oxalate exhibits significant anticancer activity against HeLa (human cervical cancer cell line). [CdL2].½H2O of ligand L-bis[5-p-nitro phenyl)-4-phenyl-1,2,4-triazole-3-dithiocatbamato hydrazide shows promising anticancer activity against Hep2 (heaptocellulare carcinoma cell line).[38,39] There are some methods of action of anticancer activity of many metal complexes of first, second, and third row d-block elements were reported and the ligands having ability to modify the pharmacological and physicochemical properties.[40] This work reports the antimicrobial and cytotoxic activity of the ligands and metal complexes. Furthermore, DFT calculations were carried out for additional information about the structure, bonding nature, and quantum chemical properties.