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Advances in Nanonutraceuticals: Indian Scenario
Published in Harishkumar Madhyastha, Durgesh Nandini Chauhan, Nanopharmaceuticals in Regenerative Medicine, 2022
Amthul Azeez, Mubeen Sultana, Lucky, Noorjahan
Curcumin reported pharmacological effects such as antioxidant, anti-inflammatory, and anti-tumour activities; however, its clinical applicability is limited due to its low availability during oral administration. Aloe vera and curcumin loaded oxidised pectin-gelatin (OP-Gel) matrices used as antimicrobial finishes on nonwoven cotton fabrics produce composite wound care devices (Tummalapalli et al. 2016). OP-Gel-Aloe treated wounds exhibited 80% of wound healing in just 8 days, further aloe vera exerted anti-inflammatory and scar prevention effects. Histological analysis revealed orderly collagen and neovascularization along with nuclei migration. OP-Gel-Aloe bio composite dressings are proposed as variable materials for effective wound management. The development of a composite material for dressing wounds with nanosilver nanohydrogel along with aloe vera and curcumin promotes antimicrobial activity with wound healing and infection control (Anjum et al. 2016).
Aloe vera Gel Extract
Published in Parimelazhagan Thangaraj, Phytomedicine, 2020
S. Govindarajan, Spoorthy N. Babu, Ayesha Noor
The present study demonstrates that the Aloe vera gel extract possesses significant anti-oxidant activity against various anti-oxidant assays and potent anti-inflammatory effects. The presence of various phenolic constituents, such as gallic acid, quercetin, myrcetin, kaempferol, and luteolin may be responsible for anti-oxidant and anti-inflammatory activities. The anti-inflammatory and anti-oxidant properties of Aloe vera might be due to the synergistic effects of these phytoconstituents. On the basis of our results, it was concluded that the Aloe vera gel extract possesses significant anti-oxidant and anti-inflammatory effects as observed by in vitro and in vivo studies. These beneficial properties of Aloe vera depend on the climate, season, mineral content, geographical origin, etc., and therefore studies are needed to check that any toxic constituents, if any, are at permissible levels. Further studies are recommended to isolate the bioactive constituents of Aloe vera and the mechanisms of action through which these constituents of Aloe vera help in reducing inflammation through the decrease of the formation of free radicals.
Synthetic electrospun nanofibers as a supportive matrix in osteogenic differentiation of induced pluripotent stem cells
Published in Journal of Biomaterials Science, Polymer Edition, 2022
Arash Azari Matin, Khashayar Fattah, Sahand Saeidpour Masouleh, Reza Tavakoli, Seyed Armin Houshmandkia, Afshin Moliani, Reza Moghimimonfared, Sahar Pakzad, Elaheh Dalir Abdolahinia
In several studies, herbal extracts have been used to induce bone regeneration at the defect sites in animal models [134–136]. It is shown that coating with herbal extracts increases the surface hydrophilicity of the scaffold, therefore, improving stem cell attachment, differentiation, and proliferation. In a study by Tahmasebi et al. [86], Aloe vera gel was used to coat the poly (3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) electrospun scaffold. The results showed that the gel enhances the osteogenic potential of the PHBV scaffold. The results of Soares et al. [135] indicated that the use of Aloe vera extract along with MSCs increases the bone regeneration of non-critical defects in an animal model. Aloe vera compounds have anti-inflammatory, anti-microbial, immune-modulating, and wound-healing properties [137]. Furthermore, Aloe vera extract contains a secondary metabolite named acemannan. This polysaccharide is involved in ECM synthesis and mineralization [138,139]. Therefore, Aloe vera has great potential in bone tissue engineering by facilitating stem cell attachment, proliferation, differentiation, and mineralization.
Molecular characterisation and antibacterial activity of Aloe barbadensis miller on textiles
Published in The Journal of The Textile Institute, 2020
Subrata Das, Arunava Das, T. Bhavya, S. Rama Nivashini
Aloe vera (Aloe barbadensis miller) gel is the clear, jelly-like substance found in the inner part of the aloe plant leaf. Aloe latex comes from just under the plant’s skin and is yellow in colour. Aloe barbadensis miller contains 99.3% water and 0.7% non-aqueous constituents, such as glycoproteins and polysaccharides, etc. Glycoproteins speed the healing process by stopping pain and inflammation (Ambikar, Phadtare, Powar, & Sharma, 2014) while polysaccharides stimulate skin growth and repair (Killoy & Polson, 1998). These substances may also stimulate the immune system. It is said to be a natural cleaner, powerful in penetrating tissues, relieving pain associated with joints and muscles, bactericidal, a strong antibiotic, virucidal when in direct contact with long periods, fungicidal, anti-inflammatory as pointed out by Mahendra, Mahendra, Muthu, John, and Romanos (2013), instrumental in increasing circulation to the area, breaking and digesting dead tissue and moisturising tissues. The strongest antibacterial effect is found in extracts of the aloe leaves and in the gel made from the inner leaves. It contains glycoproteins and polysaccharides, etc. Aloe barbadensis miller is one such product exhibiting antimicrobial activity (Kathuria, Gupta, Manisha, & Prasad, 2010; Meena, Figueiredo, & Trivedi, 2013; Rathi, 2013). Recent advances in the field of dentistry have promoted the use of Aloe barbadensis miller for treatment of various oral diseases and periodontal conditions (Richard, 2005; Taheri, Azimi, Rafieian, & Akhavan Zanjani, 2011; Tanwar, Gupta, Sheikh, Panwar, & Heralgi, 2011).
Antibacterial performances of silk fabric finished by aloe anthraquinones
Published in The Journal of The Textile Institute, 2023
Yanlai Wang, Jie Xu, Xudong Li, Yan Peng, Yina Xing, Peng Wang, Ruilong Ran, Tonghua Zhang
Anthraquinone was extracted from aloe vera based on former research (Fan, 2018). Figure 1 shows the sketch of the extraction process. First, fresh aloe vera leaves were cut into 30–40 cm, removed the gel, frozen for 12 h, vacuum-dried for 48 h, ground, and then placed in a refrigerator. Then, aloe powder (5.0 g) was added to a beaker containing 70% ethanol solution with a liquor ratio of 1: 35. Ultrasonic dispersion and vacuum filtration were used to fully extract AA into the solution (30 min, 600 W, < 25 °C). The solution was concentrated by reduced-pressure distillation to obtain a dark green solution that was freeze-dried for 48 h to obtain AA whose yield was 32%.