China
Africa
Explore chapters and articles related to this topic
Biomedical Applications of Silk Fibroin
Published in Gilson Khang, Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2017
Perforation of the tympanic membrane is one of the common diseases in the otorhinolaryngology field. Acute perforations of the tympanic membrane usually heal without treatment, with up to 80% undergoing spontaneous closure. Those that persist and become chronic usually result from infection or traumatic injury. Perforation of the tympanic membrane is usually treated by myringoplasty, where an autologous graft is applied to restore the integrity of the tympanic membrane. Typical graft materials are used, including the temporalis fascia, perichondrium, and fat. For these reasons, the development of a tissue-engineered tympanic membrane has been thoroughly investigated. Until now, several studies reported that the tissue-engineered tympanic membrane based on SF material showed successful healing in animal models.85,86–87 However, although desirable results have been reported in animal studies, there are no clinical studies until now.
3D printing technology and applied materials in eardrum regeneration
Published in Journal of Biomaterials Science, Polymer Edition, 2023
Haolei Hu, Jianwei Chen, Shuo Li, Tao Xu, Yi Li
The TM is a fine structure that captures sounds from the environment and transmits them to the ossicular chain of the middle ear. Multi-material TDP technology can overcome the limitations of existing graft materials, such as the temporal muscle fascia, in surgical reconstruction of the TM. Kozin ED et al. (2016) prepared 8 or 16 totally and radially aligned TM graft scaffolds by 3D-printing polydimethylsiloxane (PDMS), polylactide (PLA), and polycaprolactone (PCL) materials, followed by uniform filling of fibrin-collagen composite hydrogels [6]. Digital photoelectron holography (DOEH) and a laser Doppler vibriometer (LDV) were used to measure the response of TM grafts to sound, including surface motion and velocity. Dynamic mechanical analysis (DMA) was used to measure the mechanical properties. Design, fabrication, and preliminary in vitro acoustic and mechanical evaluation of 3D printed TM grafts was conducted. The data demonstrate the feasibility of using acoustic properties to create TM grafts that can reflect the acoustic motion patterns of human TM. Additionally, the 3D-printed grafts were more resistant to deformation than the temporal fascia (Figures 3 and 4).