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Applications of imaging genomics beyond oncology
Published in Ruijiang Li, Lei Xing, Sandy Napel, Daniel L. Rubin, Radiomics and Radiogenomics, 2019
Xiaohui Yao, Jingwen Yan, Li Shen
One GWAS has identified a novel gene transmembrane protein 106B (TMEM106B) associated with FTD-TDP, as well as increased risk of FTLD-TDP in individuals with GRN mutations [89]. Several other rare FTD risk genes, including charged multivesicular body protein 2B (CHMP2B), valosin containing protein (VCP), sequestosome 1 (SQSTM1), transactive response DNA-binding protein (TARDP), FUS, Tank-binding kinase 1 gene (TBK1), and coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10), have also been reported in small family studies [81, 86–88, 90–92]. Diekstra et al. [93] performed a meta-analysis of GWAS and reported two shared genetic associations of FTD and ALS including C9orf72 and a novel gene unc-13 homolog A (UNC13A). Although the above common and rare genetic findings have contributed to the risk of different types of FTLD, some portion of disease heritability is still unexplained. In addition, the molecular mechanism of disease is not fully understood due to limited statistical power of case-control study and complex pathology of FTD.
Detoxifying effects of optimal hyperoxia (40% oxygenation) exposure on benzo[a]pyrene-induced toxicity in human keratinocytes
Published in Journal of Toxicology and Environmental Health, Part A, 2020
Yong Chan Kwon, Hyung Sik Kim, Byung-Mu Lee
Dulbecco’s modified Eagle’s medium (DMEM), fetal bovine serum (FBS), and antibiotic-antimycotic (A.A.) were purchased from Thermo Fisher Scientific (Waltham, MA). Benzo[a]pyrene (B[a]P), dimethylsulfoxide (DMSO), and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) were purchased from Sigma-Aldrich (St. Louis, MO). Primary antibodies for p38 mitogen-activated protein kinases (p38 MAPK), the phosphorylation form of nuclear factor kappa-light-chain-enhancer of activated B cells (p-NF-κB), glycogen synthase kinase 3 beta (GSK-3β), p-GSK-3β, p62 (also known as sequestosome-1), and sirtuin 2 (SIRT2) were procured from Cell Signaling Technology (Danvers, MA). Primary antibodies for p-p38 MAPK, peroxisome proliferator-activated receptor (PPARα), heme oxygenase-1 (HO-1), glutathione peroxidase-1/2 (GPX-1/2), β-actin and matrix metalloproteinase-2/9 (MMP2/9) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA). Primary antibodies for nuclear factor erythroid 2-related factor 2 (Nrf2), hypoxia-inducible factor 1-alpha (HIF-1α), superoxide dismutase 2 (SOD2) and sirtuin 1 (SIRT1) were procured from Abcam (Cambridge, MA). Anti-rabbit IgG secondary antibody was purchased from Genetex (Irvine, CA) and anti-mouse IgG secondary antibody was obtained from Novus Biologicals LLC (Centennial, CO).