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Applications of Starch in the Bioeconomy
Published in Jean-Luc Wertz, Bénédicte Goffin, Starch in the Bioeconomy, 2020
Jean-Luc Wertz, Bénédicte Goffin
There are two broad methodologies for manipulating plants through biotechnological means: reverse genetics, which are targeted approaches, and forward genetics, which are open-end approaches (Figure 6.2). The forward genetics approach uses variation in the trait among different individuals and then seeks to identify the causal gene. The reverse genetics approach starts with a candidate gene of unknown function but based on indicative sequence motifs or domains present, it may be predicted to be involved in a particular process(es), which is then tested. Often, candidate genes identified by forward genetics are verified using reverse genetics.
Glossary of scientific and technical terms in bioengineering and biological engineering
Published in Megh R. Goyal, Scientific and Technical Terms in Bioengineering and Biological Engineering, 2018
Reverse genetics is an approach to discover the function of a gene by analyzing the phenotypic effects of specific gene sequences obtained by DNA sequencing. This investigative process proceeds in the opposite direction of so-called forward genetic screens of classical genetics.
Coronavirus
Published in Suman Lata Tripathi, Kanav Dhir, Deepika Ghai, Shashikant Patil, Health Informatics and Technological Solutions for Coronavirus (COVID-19), 2021
Reverse genetics is a molecular method that is known to determine the functions of a gene. This is done by analyzing the phenotypic effects that are results of genetically engineered specific nucleic acid sequences within the gene.
Transhumanist Genetic Enhancement: Creation of a ‘New Man’ Through Technological Innovation
Published in The New Bioethics, 2021
The possibility of genome editing for altering specific phenotypic traits has to be based on knowing what genes are related to traits of interest and how they need to be altered to obtain the desired outcome. A central goal of genetics is to understand the links between genetic variations and traits and diseases by using reverse or forward genetics. Reverse genetics is the determination of the function(s) of a gene by correlating phenotypic effects with variations in DNA sequences. Forward genetics is determining the genetic basis of a phenotype.