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Biology of Coronaviruses with Special Reference to SARS-CoV-2
Published in Joystu Dutta, Srijan Goswami, Abhijit Mitra, COVID-19 and Emerging Environmental Trends, 2020
Joystu Dutta, Srijan Goswami, Abhijit Mitra
Ribosome frame shifting during genome translation: This can be observed during the initial production of polyproteins, which are actually used to generate most of the protein machinery of the replisome or transcriptosome.
Recombinant expression and characterization of yeast Mrc1, a DNA replication checkpoint mediator
Published in Preparative Biochemistry & Biotechnology, 2020
Mrc1, a mediator of replication checkpoint, is a component of DNA replisome that moves along the chromosome with the replication fork during DNA synthesis.[12,13] At the same time, Mrc1 is also involved in the response of S. cerevisiae cells to hydroxyurea [HU]. When DNA replication is blocked by HU, Mrc1 undergoes Mec1-dependent phosphorylation, which acts as an intermediary and participates in the process of transmitting the replication stress signal from Mec1 to the Rad53 effector kinase.[14–16] In this process, Rad17-RFC (Rad24-RFC in yeast) also plays an important role in regulating the phosphorylation of Claspin (Mrc1 in yeast).[17]
Novel horizons of the conformationally-tautomeric transformations of the G·T base pairs: quantum-mechanical investigation
Published in Molecular Physics, 2022
Ol’ha O. Brovarets’, Alona Muradova, Dmytro M. Hovorun
All calculations have been carried in vacuum, reflecting the processes occurring in real biological systems without deprivation of the structurally functional properties of the bases in the composition of DNA and satisfactorily modeling the substantially hydrophobic recognition pocket of the DNA-polymerase machinery as a part of the replisome [117,118].