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Published in Michael Hehenberger, Zhi Xia, Huanming Yang, Our Animal Connection, 2020
Michael Hehenberger, Zhi Xia, Huanming Yang
Later in 2014 it was shown by a team at University of Pittsburg that similar pig bladder scaffolds could be used to regenerate leg muscles.179 Although muscle has the ability to regenerate naturally, it cannot refill massive defects, such as those seen in volumetric muscle loss (VML). In response, the team implanted a biomaterial scaffold at the site of VML, encouraging local muscle regeneration and improving function in both mice and humans. The biomaterial used in this study was made up of pig bladder tissue that had been stripped of cells, leaving behind only the protein scaffold called the extracellular matrix (ECM). There was new skeletal muscle formation including striated (striped) tissue organization. The new muscle was also was innervated, which is necessary for function. The preclinical work was then translated into a clinical study of five patients with VML and outcomes were similar to the mice. Six months after ECM implantation at the site of muscle loss, all patients showed signs of new muscle and blood vessels. Three of the five patients showed 20% or greater improvement in limb strength during physical therapy.
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Published in Michael Hehenberger, Zhi Xia, Our Animal Connection, 2019
Later in 2014 it was shown by a team at University of Pittsburg that similar pig bladder scaffolds could be used to regenerate leg muscles.179 Although muscle has the ability to regenerate naturally, it cannot refill massive defects, such as those seen in volumetric muscle loss (VML). In response, the team implanted a biomaterial scaffold at the site of VML, encouraging local muscle regeneration and improving function in both mice and humans. The biomaterial used in this study was made up of pig bladder tissue that had been stripped of cells, leaving behind only the protein scaffold called the extracellular matrix (ECM). There was new skeletal muscle formation including striated (striped) tissue organization. The new muscle was also was innervated, which is necessary for function. The preclinical work was then translated into a clinical study of five patients with VML and outcomes were similar to the mice. Six months after ECM implantation at the site of muscle loss, all patients showed signs of new muscle and blood vessels. Three of the five patients showed 20% or greater improvement in limb strength during physical therapy.
Computational modeling of inhibitory signal transduction in urinary bladder PDGFRα+ cells
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2023
Amritanshu Gupta, Rohit Manchanda
While the application of NO agonist suppresses detrusor contractions in whole bladder preparations (Mumtaz et al. 2000; Mamas et al. 2003), it is noteworthy that in isolated guinea pig bladder preparations, NO did not have a significant impact on dSMCs. This observation underscores the point that while NO does induce inhibitory responses in dSMCs, it is not through direct signal transduction but via an intermediary entity. PDGFRα+ cells, in theory, have the molecular machinery to transduce NO-mediated inhibitory signalling and their interconnection with dSMCs provides a pathway for the inhibitory responses, which manifests as hyperpolarization of the membrane as seen in our model simulations (Figure 7).