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Bacterial Attachment and Biofilm Formation on Biomaterials
Published in Nihal Engin Vrana, Biomaterials and Immune Response, 2018
The most alarming issue in PJI is fast-growing resistance of bacterial strains against all known antibiotics and antibacterial drugs. Recent discovery [7] of the fast-spreading polymyxin-resistant mcr-1 gene in bacteria present in live feedstock and environment leaves little space of success for any antibiotics to treat possible PJI [8].
Occurrence of clinically relevant antimicrobial resistance genes, including mcr-3 and mcr-7.1, in soil and water from a recreation club
Published in International Journal of Environmental Health Research, 2022
João Pedro Rueda Furlan, Lucas David Rodrigues Dos Santos, Micaela Santana Ramos, Inara Fernanda Lage Gallo, Jéssica Aparecida Silva Moretto, Eliana Guedes Stehling
The presence of mcr-like genes in environmental samples is highlighted since mcr-like genes confer resistance to polymyxins, which are considered one of the last-resort antimicrobials used to treat infections caused by MDR pathogens (Poirel et al. 2017). In 2016, the mcr-1 gene was described for the first time as the first mobilized resistance mechanism to polymyxins (Liu et al. 2016). Subsequently, different mcr-like genes were described, including the mcr-3 gene in pigs and the mcr-7.1 in chickens. The mcr-3-like genes are close to mcr-7.1 and are probably derived from Aeromonas species that are prevalent in aquatic environments. Therefore, this fact may explain the detection of mcr-like genes only in water samples (Yin et al. 2017; Yang et al. 2018). Among the mcr-like genes, mcr-1 and mcr-3 have been reported worldwide in different spheres, such as humans, food, animals and the environment (Wise et al. 2018; Wang et al. 2018a). In Brazil, the mcr-1 gene has been reported in clinical and environmental samples while the mcr-3 was reported only once in swine samples (Fernandes et al. 2017; Conceição-Neto et al. 2017; Rossi et al. 2017; Rau et al. 2018; Kieffer et al. 2018).