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Gastrointestinal tract and salivary glands
Published in A Stewart Whitley, Jan Dodgeon, Angela Meadows, Jane Cullingworth, Ken Holmes, Marcus Jackson, Graham Hoadley, Randeep Kumar Kulshrestha, Clark’s Procedures in Diagnostic Imaging: A System-Based Approach, 2020
A Stewart Whitley, Jan Dodgeon, Angela Meadows, Jane Cullingworth, Ken Holmes, Marcus Jackson, Graham Hoadley, Randeep Kumar Kulshrestha
CT has proved to be a valuable adjunct to barium studies and endoscopy in the evaluation of gastric disease. It can be utilised for detecting and delineating gastric neoplasms, such as lymphoma and leiomyosarcoma, in addition to metastasis to the stomach. It is used for the TNM* staging of gastric cancer and in the diagnosis of benign tumours, all forms of gastritis, gastric ulcers and gastric varices [23; 24]. Multidetector technology has resulted in CT being used increasingly to generate virtual gastroscopic images, providing a viable alternative to an often less well-tolerated and invasive endoscopic examination [25]. Virtual gastroscopy must be accompanied by MPRs as it unable to assess the depth of a lesion [26].
Clinical Photodynamic Therapy: The Continuing Evolution
Published in Barbara W. Henderson, Thomas J. Dougherty, Photodynamic Therapy, 2020
Endobronchial obstructive tumors metastatic to lung responded well to PDT with 44/50 (88%) sites producing a CR, with total CR plus PR response of 47/50 (94%). It is of note that 10/19 patients with metastatic disease had conditions known to be refractory to other standard forms of cytotoxic or radiation therapy (melanoma, osteogenic sarcoma, renal cell carcinoma, and leiomyosarcoma).
A critical review of talc and ovarian cancer
Published in Journal of Toxicology and Environmental Health, Part B, 2020
Julie E. Goodman, Laura E. Kerper, Robyn L. Prueitt, Charlotte M. Marsh
Wagner et al. (1977) reported no clear evidence of carcinogenicity in rats following an intrapleural inoculation with 20 mg Italian 00000 grade talc or dietary exposure to 100 mg/day Italian talc on 101 days over a 5-month period. This Italian talc (mean particle size 25 µm) was selected for the experiments due to its 50-year history of use and because it served as the source of over 40% of cosmetic grade talc in Great Britain at the time. In the rats exposed via intrapleural inoculation, injection site granulomas were reportedly common and one small pulmonary adenoma was identified as a possibly incidental finding. In the dietary portion of the experiment, a single leiomyosarcoma of the stomach was detected in a talc-fed rat, but Wagner et al. (1977) were unable to determine whether it was related to exposure. In addition, two sarcomas of the uterus were found in treated rats but were not considered treatment related due to the location of the tumors and occurrence of this tumor type in historical control animals.