Ischemic optic neuropathy

Ischemic optic neuropathy is a condition in which the optic nerve is damaged due to reduced blood flow to the eye, leading to irreversible vision loss in 10%–15% of cases. It is often associated with ocular ischemia and can be caused by increasing reactive oxygen species (ROS) in the retina ganglion cells (RGCs). It is also linked to various diseases such as glaucoma, hereditary optic atrophy, Traumatic Optic Neuropathy, and Optic Neuritis.From: Multi-Detector CT Imaging [2019], The therapeutic effect of nano-zinc on the optic nerve of offspring rats and their mothers treated with lipopolysaccharides [2023]

Gene Therapy for Retina and Eye Diseases

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Published in Yashwant V. Pathak, Gene Delivery Systems, 2022

Khushboo Faldu, Jigna Shah

Small vessel infarction of the anterior optic nerve leads to the development of optic neuropathy, also identified as non-arteritic anterior ischemic optic neuropathy. Risk factors include old age, diabetes mellitus, obstructive sleep apnea, and hypertension. It causes loss of vision (53).

The therapeutic effect of nano-zinc on the optic nerve of offspring rats and their mothers treated with lipopolysaccharides

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Published in Egyptian Journal of Basic and Applied Sciences, 2023

Eman Mohammed Emara, Hassan Ih El-Sayyad, Amr M Mowafy, Heba a El-Ghaweet

Many studies demonstrated that injecting bacterial LPS into the optic nerve of rats induced optic neuritis (ON). ON is characterized by a disruption of the blood-brain barrier (BBB) and leukocyte infiltration, as well as unilateral visual loss, afferent pupillary deficiency, abnormal visual evoked potentials (VEPs), periocular or retro-orbital pain in conjunction with eye movement, astrocytosis, demyelination, axon degeneration and RGC degeneration [12]. RGC oxidative damage is caused by increasing reactive oxygen species (ROS), and it is associated with numerous diseases such as glaucoma, hereditary optic atrophy, ischemic optic neuropathy, Traumatic Optic Neuropathy and Optic Neuritis. LPS injections also increased the levels of inducible nitric oxide synthase, COX-2, interleukin-1β and TNFα mRNA levels as well as increased the production of retinal superoxide, decreased activity of superoxide dismutase 2 and activated the inflammasome. All previous findings have been associated with optic nerve damage [13].

Ischemic optic neuropathy

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Gene Therapy for Retina and Eye Diseases

The therapeutic effect of nano-zinc on the optic nerve of offspring rats and their mothers treated with lipopolysaccharides