Ionotropic glutamate receptors

An ionotropic glutamate receptor is a type of receptor located at the membranes of neuronal cells that mediates fast excitatory synaptic transmission in the central nervous system (CNS). It plays a key role in synaptic plasticity and is one of three types of ionotropic glutamate receptors, the others being the AMPA and kainate receptors.From: Handbook of Luminescent Semiconductor Materials [2019], A DFT approach to discriminate the antagonist and partial agonist activity of ligands binding to the NMDA receptor [2018], Electrical Brain Stimulation for the Treatment of Neurological Disorders [2019]

Computational Neuroscience and Compartmental Modeling

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Published in Bahman Zohuri, Patrick J. McDaniel, Electrical Brain Stimulation for the Treatment of Neurological Disorders, 2019

Bahman Zohuri, Patrick J. McDaniel

Note that, the N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors, the others being the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane.99 The NMDA receptor is very important for controlling synaptic plasticity and memory function.100

A DFT approach to discriminate the antagonist and partial agonist activity of ligands binding to the NMDA receptor

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Published in Molecular Physics, 2018

Zeynep Pinar Haslak, Esra Bozkurt, Bercem Dutagaci, Frank De Proft, Viktorya Aviyente, Freija De Vleeschouwer

Ionotropic glutamate receptors (iGluRs) are located at the membranes of neuronal cells and play key roles in synaptic plasticity. Monomers of iGluRs contain an extracellular N terminal domain (NTD), an intracellular C terminal domain (CTD), three transmembrane domains (M1, M2 and M3), a re-entrant membrane loop (P-loop) and a ligand binding domain (LBD) [1]. iGluRs act as cation-selective ion channels upon binding of agonists to their LBDs. They can be classified into three main groups with respect to the affinities of specific agonists N-methyl-D-aspartate (NMDA), kainic acid (KA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) [2].

Ionotropic glutamate receptors

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Computational Neuroscience and Compartmental Modeling

A DFT approach to discriminate the antagonist and partial agonist activity of ligands binding to the NMDA receptor