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Polymeric Hydrogels for Controlled Drug Delivery
Published in Munmaya K. Mishra, Applications of Encapsulation and Controlled Release, 2019
Hira Ijaz, Farooq Azam, Ume Ruqia Tul-Ain, Junaid Qureshi
Hydroxyethyl cellulose (HEC) is a crucial spinoff cellulose polysaccharide, which has wide application in drug delivery. It is highly water soluble and non-ionic. It is employed as a thickening agent in emulsions and suspension and for film formation and water retention, and is therefore used for formulating hydrogels for controlled drug delivery. The water retention capacity of HEC is twice that of alkyl polysaccharides, thereby leading to a stronger colloid [54] ( [Figure 3.11). HEC is biocompatible and biodegradable with film-forming ability. It is employed as a thickening and viscosity-increasing agent (viscosifier) in the food, cosmetic, biophysical, and biotechnological industries55]. Structure of hydroxyethyl cellulose.
Development of biomimetic electrospun polymeric biomaterials for bone tissue engineering. A review
Published in Journal of Biomaterials Science, Polymer Edition, 2019
Sugandha Chahal, Anuj Kumar, Fathima Shahitha Jahir Hussian
Hydroxyethyl cellulose (HEC) is a cellulose derivative, in which ethyl group replaces one or more of three hydroxyl groups, which are present in each glucopyranoside. The degree of substitution and their relative distribution in C1, C2 and C6 positions strongly affect the properties and behavior of these polymers [141]. HEC was discovered and patented for manufacturing process by Hagedom et al. [142]. They produce the HEC by reacted the cellulose with ethylene oxide in the presence of sodium hydroxide. HEC is hydrophilic polysaccharide biopolymers with β (1→4) glycosidic linkage (refer to Figure 16). The chemical structure of HEC exactly matches that of the glycosaminoglycans (GAGs) of the matrix. HEC has bulk density 300 – 600 kg/m3, tensile strength 36 - 76 MPa, elongation% 6 - 7 and elastic modulus 590 MPa [144]. The glass transition and decomposition temperatures of HEC range between 120 – 125 °C and 205 – 210 °C respectively [144].
Analysis of the physicochemical properties of antimicrobial compositions with zinc oxide nanoparticles
Published in Science and Technology of Advanced Materials, 2019
Jolanta Pulit-Prociak, Jarosław Chwastowski, Laura Bittencourt Rodrigues, Marcin Banach
Hydroxyethyl cellulose (HEC) is a water-soluble cellulose derivative. It is largely used as a thickening, suspending and stabilizing agent. HEC is obtained from the etherification reaction between cellulose and ethylene oxide [19]. Hydroxyethyl cellulose is applied in cosmetic, textile, paint, and food industries. It is gaining interest because of its non-ionic, non-toxic, water-retaining, solubility, and film-forming properties. HEC has been used to improve the rheological properties of suspensions, making them more elastic as the shear is increased [20,21].