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Tunable Hydrogel Systems for Delivery and Release of Cell-Secreted and Synthetic Therapeutic Products
Published in Emmanuel Opara, Controlled Drug Delivery Systems, 2020
Kylie G. Nairon, Thomas DePalma, Hemamylammal Sivakumar, Aleksander Skardal
Hydrogels possess most of the qualities of an ideal wound dressing – the most important qualities being able to maintain wettability in the wound zone, the ability to control the lost fluids and liquid from the body, and possessing tissue-like structure and compatibility.73 It was demonstrated by the work of George Winter that maintaining a moist wound environment is of paramount importance in wound healing and resulted in faster epithelization than under a dry scab.70 This makes hydrogels a material of choice for burn patients with an added advantage of being able to maintain a cool surface temperature.74 Hydrogels are advised to be applied to burn wounds if running cold water is unavailable to cool the surface of the wounds and provide pain relief and reduce the damage of the wounds.75 Hydrogel dressings provide unique advantages such as often being nonadherent, easily removable, promoting wound healing, and reducing inflammatory reaction and pain.73 Many hydrogels are also relatively inexpensive and easily developed and handled.73
A short review on chitosan and gelatin-based hydrogel composite polymers for wound healing
Published in Journal of Biomaterials Science, Polymer Edition, 2022
As a result, Chen et al [119] fabricated covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing using emulsion crosslinking technique. These are antibiotic – incorporated microspheres introduced into the gel scaffolds, which not only ensures sustained drug release, but similarly enhances mechanical properties. The objective of the study was to improve the mechanical and drug delivery performances of the natural hydrogels. These antibacterial composite hydrogel dressing therapeutically enhance wound healing through infection treatment. To illustrate, action of growth inhibition was demonstrated against E. coli and S. aureus. These micro-organisms while ubiquitous, often proliferate after infection [120,121], which explains why they have been used in this study (Figure 1).
Dual-acting antibacterial porous chitosan film embedded with a photosensitizer
Published in Science and Technology of Advanced Materials, 2020
Zi-Jun Liu, Shu-Ching Lin, Pei-Yuan Lee, Ying-Ting Lin, Zi-Lun Lai, Cheng-Chung Chang, Gou-Jen Wang
To reduce the impact of antibiotic use, scientists have successively developed new antibacterial ingredients, methods, and dressings that effectively promote wound healing, allowing wounds to have better healing effects through the treatment with external dressings. Antibacterial dressings have been one of the hot research topics in the field of wound treatment. Thakur et al. [1] synthesized ZnO nanoparticle-loaded sodium alginate gum acacia (SAGA-ZnONPs) hydrogels and demonstrated that the proposed SAGA-ZnONP hydrogels significantly reduced the toxicity of ZnONPs and preserved the healing effect at a low concentration of ZnONPs. Zhao et al. [2] proposed an antibacterial, anti-oxidant, and electroactive dressing based on quaternized chitosan (Cs)-g-polyaniline and benzaldehyde group-functionalized poly(ethylene glycol)-co-poly(glycerol sebacate). Experimental results showed that the proposed hydrogel dressing could prolong the lifespan of dressing and promote the in vivo wound healing process. Zhang et al. [3] developed a three-dimensional (3D) layered nanofiber sponge to enhance the interfacial interaction between the sponge and blood cells to accelerate hemostasis. The fabricated 3D sponge could promote the regeneration of functional dermis and the restoration of differentiated adipocytes during the early repair phase. Wu et al. [4] prepared a nontoxicity and antimicrobial hydrogel P(M-Arg/NIPAAm) and demonstrated that the proposed hydrogel could effectively accelerate the full-thickness wound healing process.
Medical textiles
Published in Textile Progress, 2020
Hydrogel dressings are available in the form of a gelatinous sheet or an amorphous wound filler. They can be used to fill wound defects, such as loss of tissue creating a cavity, and also conform well to wound surfaces. They are non-adhesive, permeable to gases and have a high water content which aids granulation and also provides a cooling and thus soothing effect. As they provide little absorption, they should be used on a dry or lightly-exudative wound to maintain a moist surface; indeed burns appear to heal quicker with hydrogel dressings than with standard care [402]. Use on a heavily-draining wound may lead to maceration and bacterial overgrowth [394, 403].