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Informatics For Sciences: A Novel Approach
Published in Alexander V. Vakhrushev, Omari V. Mukbaniani, Heru Susanto, Chemical Technology and Informatics in Chemistry with Applications, 2019
Heru Susanto, Ching Kang Chen, Teuku Beuna Bardant
According to Ma and Liu5 genomics is a large-scale data acquisition, technological advancements that involve genome structures, evolution, and variations. Genomics origin can be traced as far back to the 19th century from the work of Gregor Mendel. However, in the middle of 19th century, the progress of IS and IT was not advanced as it is today. It is important to remember that genomics is an essential area of bioinformatics, as well as understanding its roles in the milestones of biological and molecular discovery. For instance, in Human Genome Project: an international scientific research project with goals to determine what makes up human DNA and its physical and functional characteristics, understanding heredity and diseases, and its role in pushing the innovation in genomic technologies, and many more. Another view on genomics is that the main concept of genome informatics was to analyze, process, and interpret all aspects of DNA in order to come up with a more defined and accurate information on biological structure and components of DNA.1 All things considered, genomics is evolving duly because IT and IS keep on improving throughout the years. Owing to this, the world is progressing at a much faster pace, namely in biomedicine and microbiology, and the knowledge that it brought, had or are still being used to broaden our views on molecular mechanisms in the spreading, treating, curing, and preventing the development of diseases.
IoT Cloud Network for Healthcare
Published in Sanjay Kumar Biswash, Sourav Kanti Addya, Cloud Network Management, 2020
Ashok Kumar Pradhan, E. Bhaskara Santhosh, S Priyanka
As a result of advancements made through the Human Genome Project[111] in understanding a person’s genetic makeup which determines their susceptibility to certain diseases, it is now possible to provide tailored therapies suitable for each patient, thereby making them safer and effective. Personalized medicine takes into account not just the genetic makeup of individuals but also their preferences, beliefs, attitudes, knowledge and social context. On the other hand, precision medicine utilizes patient centrism, engagement, digital health application, genomics, molecular technologies and data sharing in healthcare delivery.
Personalized Medicine and a Data Revolution
Published in Ahmed Elngar, Ambika Pawar, Prathamesh Churi, Data Protection and Privacy in Healthcare, 2021
Subhajit Basu, Adekemi Omotubora
It is well known that genomics can improve the treatment of disease, because of learning from the Human Genome Project and subsequent scientific work.Molecular data analysis based on genetic data acquired from large numbers of people can provide not only a massive volume of health-related information, but also a diversity in the kinds of information we can derive, from responsiveness to drugs, to likelihood of contracting a particular disease, and ways to prevent or reduce the risk of certain diseases later on in life.[1]
Epigenotoxicity: a danger to the future life
Published in Journal of Environmental Science and Health, Part A, 2023
Farzaneh Kefayati, Atoosa Karimi Babaahmadi, Taraneh Mousavi, Mahshid Hodjat, Mohammad Abdollahi
Since completing the Human Genome Project about twenty years ago, there has been a great deal of help from geneticists and physicians regarding having access to the human genome map and better diagnosing diseases. Today, epigenetics has enabled us to understand the complexities of the human biological system and the body’s processes of growth and regulation. Epigenetics indicates that the sequence of nucleotides and their bonds with different functional groups is crucial in DNA function [88] Mistakes in epigenetic mechanisms alter the expression of genes causing a range of disorders. Amongst, developmental and mental disorders, immunodeficiency, Chronic obstructive pulmonary disease (COPD), asthma, and organ defects, are the most common; each will be discussed separately below as well as in Table 2.[88,89]
Progressing the health agenda: responsibly innovating in health technology*
Published in Journal of Responsible Innovation, 2018
Some may ask the question: Have there been initiatives that have been successful or unsuccessful because of their consideration – or lack of consideration – of ethical, legal, and social concerns? Several would contend that the Human Genome Project has led to substantial gains in understanding genetics and genomics (National Human Genome Research institute 2015). Ethical, legal, and social considerations were examined at the outset and continued throughout the program (Collins 1999; Collins, Morgan, and Patrinos 2003). Today, there are consumer tests that provide ancestry information based on a saliva swab in addition to a newly federally funded Precision Medicine Initiative to advance the Human Genome Project (Precision Medicine Initiative Cohort Program 2016). Is the public more comfortable with genetic testing having explored ethical, legal, and social implications early on in the initiative? Probably. Genetically modified foods (GMOs) are one example where the scientific community has been less effective at addressing these concerns. In many countries, GMOs are shied away from because of the belief that they are unnatural or will cause other problems (Gaskell et al. 2000). This is despite the fact that GMOs have potential to help minimize global hunger (see, for example, Pinstrup-Andersen and Schiøler 2003).