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Macrocyclic Receptors for Environmentally Sensitive Metal Ions
Published in Satish Kumar, Priya Ranjan Sahoo, Violet Rajeshwari Macwan, Jaspreet Kaur, Mukesh, Rachana Sahney, Macrocyclic Receptors for Environmental and Biosensing Applications, 2022
Satish Kumar, Priya Ranjan Sahoo, Violet Rajeshwari Macwan, Jaspreet Kaur, Mukesh, Rachana Sahney
Similarly, alkali metal ions complexation behavior with pillararene receptors in methanol was examined using the UV-Vis technique by Yakimova and coworkers. Three pillar[5]arenes 2-4 containing piperidine, glycine, glycylglycine units, respectively were prepared. The three receptors were found to bind with alkali metal ions with 1:1 stoichiometry with the most effective binding efficiency for Li+ ions over other alkali and transition metal ions. The complex results revealed that the receptor 4 bearing long glycylglycine fragments was the most efficient receptor towards all the alkali metal ions tested (Yakimova et al. 2017).
Established and Novel Excipients for Freeze-Drying of Proteins
Published in Davide Fissore, Roberto Pisano, Antonello Barresi, Freeze Drying of Pharmaceutical Products, 2019
Ivonne Seifert, Wolfgang Friess
Glycylglycine is used as buffering agent for stabilisation of freeze-dried factor VIIa (NovoSeven®), which showed, along with glycine, stabilising effects during freeze-thaw experiments (Enomoto 1989), but a specific stabilising effect in lyophilisation has not been reported yet (Lim et al. 2016; Jensen et al. 2012).
Physical Constants of Organic Compounds
Published in W. M. Haynes, David R. Lide, Thomas J. Bruno, CRC Handbook of Chemistry and Physics, 2016
W. M. Haynes, David R. Lide, Thomas J. Bruno
Glycerone phosphate Glycine Glycine, ethyl ester, hydrochloride Glycine, hydrochloride Glycocholic acid Glycocyamine Glycogen Glycolaldehyde Glycolic acid N-Glycolylneuraminic acid Glycopyrrolate Glycylalanine L-Glycylasparagine N-Glycylglycine
Insight into intermolecular interactions and hydration properties of biologically active amino acids in aqueous solutions of cefepime: volumetric, compressibility and viscometric studies
Published in Journal of Dispersion Science and Technology, 2021
Suvarcha Chauhan, Neetika Kumari, Lalita Pathania
The drug − protein interactions are generally difficult to study because of the complex structure of protein molecules. However, to reduce the degree of complexity, it is useful to investigate the solution behavior of model compounds such as amino acids, dipeptides etc. Drug can interact with these amino acids and small peptides to change the conformation of proteins either by stabilizing or destabilizing them. The recognition of drug-amino acid/peptide interactions in aqueous solution has always been a matter of interest.[3,4] Therefore, physico-chemical investigations are carried out for amino acids/peptides in aqueous solutions of different types of drugs. Among amino acids and peptides, glycine and glycylglycine have been chosen for the present study. Glycine is the simplest possible amino acid and is biosynthesized in the body from the amino acid serine.[5] It plays an important role in the body's production of DNA, phospholipids and collagen, and in release of energy besides acting as neurotransmitter. Glycylglycine is dipeptide made up of two glycine molecules joined by peptide linkage and is used in the synthesis of more complicated peptides.
Phase behaviour, structural properties and intermolecular interactions of systems based on substituted thiacalix[4]arene and nonionic surfactants
Published in Liquid Crystals, 2019
Natalia Selivanova, Aidar Gubaidullin, Pavel Padnya, Ivan Stoikov, Yuriy Galyametdinov
It has been found that thiacalixarenes with flexible alkyl substituents (R = COCnH2n+1, n = 9–21) form columnar liquid crystal phases. In the presence of certain organic solvents, however, they form lyotropic mesomorphism and form head-to-tail organised structures by hydrogen bonding [17]. In our case, glycine groups and quaternary ammonium fragments favour macrocycle hydrophilisation and, therefore, make it highly soluble in water. However, no LC properties can be observed for the individual compound. Amphiphilic С12ЕО4 form a lamellar lyomesophase in water. The rearrangement of the supramolecular organisation to a hexagonal phase observed in the presence of the macrocycle indicates incorporation of thiacalix[4]arene molecules into the aqueous space of cylindrical surfactant micelles. Self-assembly of macrocycles may occur in this case. It initiates formation of rod-like domains typical for proteins enriched with glycyl-glycine fragments responsible for hexagonal packing of molecules.