China
Africa
Explore chapters and articles related to this topic
Tissue Fabrication and Regeneration by Cell Sheet Technology
Published in Gilson Khang, Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2017
Yuji Haraguchi, Tatsuya Shimizu, Masayuki Yamato, Teruo Okano
Endoscopic mucosal resection (EMR) and esophageal endoscopic submucosal dissection (ESD) enable the effective removal of early cancers on the gastrointestinal tract without the requirement of a conventional open surgery.100,101,102–103 While the therapies are relatively noninvasive, the resection of the cancerous epithelial and mucosal layers results in the defect of normal epithelial barrier function in the treated areas. Postoperative inflammation and stenosis are major complications after the surgery and substantially affect patient quality of life.104,105 For preventing the postoperative stenosis, several therapies including periodic balloon dilations have performed.106,107 However, in the authors’ laboratory, a therapy for preventing the formation of strictures with oral mucosal epithelial cell sheets, which are autologously collected from patients’ own oral mucosa and fabricated, is established and has been clinically performed.108,109 The clinical study was performed on 9 patients, the resected size of mucosa by ESD ranged from half to the full inner circumference of the esophagus, and 2–8 cell sheets, approximately 6 mm in diameter, were endoscopically transplanted onto the ulcer sites without any suturing. The therapy gave a good clinical outcome, and no patients with partial circumferential resection experienced dysphagia, stricture, or other complications after the therapy except for one patient, who had a large esophageal ulceration with a full circumference expanding to the esophagogastric junction. On the basis of these encouraging results, in Karolinska University Hospital (KUH) (Stockholm, Sweden), a clinical study for esophagus diseases such as Barrett’s esophagus was performed.
Predicting and managing complications following colonoscopy: risk factors and management of advanced interventional endoscopy with a focus on colorectal ESD
Published in Expert Review of Medical Devices, 2020
Hiroyuki Takamaru, Rina Goto, Masayoshi Yamada, Taku Sakamoto, Takahisa Matsuda, Yutaka Saito
Delayed perforation is one of the most serious complications after endoscopic resection. Early detection and surgical treatment are essential [47,48]. Laboratory data by both endoscopists and surgeons should be evaluated as well [2,9,19,25]. Post endoscopic submucosal dissection coagulation syndrome (PECS), or traditionally known as post polypectomy coagulation syndrome is another important complication after endoscopic treatment we should focus on [49,50]. A long duration of electric currency during EMR can cause excessive burning effects and increases the risk of this syndrome [49]. The risk of PECS was summarized by pooled analysis without any statistical differences due to a limited number of studies (Figure 3). Several studies reported the efficacy of closing mucosal defects to prevent or minimalized PECS after endoscopic treatment in the gastrointestinal tract [35,51]. Burgess et al. reported the ‘Sydney classification of deep mural injury (DMI)’ and showed Type III–V were a risk for delayed perforation [52].
Smart connected electronic gastroscope system for gastric cancer screening using multi-column convolutional neural networks
Published in International Journal of Production Research, 2019
Hao Wang, Shuai Ding, Desheng Wu, Youtao Zhang, Shanlin Yang
The recent advances in endoscopy led to the development of novel gastric cancer detection methods, such as endoscopic ultrasonography (EUS) (Pyo et al. 2016) and endoscopic submucosal dissection (ESD) (Nagar 2017). However, the advances in gastroscopy equipment and computer aided diagnosis techniques have not substantially mitigated the global prevalence of gastric cancer. For example, while most hospitals in major cities in China have the capacity to perform gastroscopy, the mortality rates from gastric cancer are still approximately 15% in such cities.
OverStitch Sx Endoscopic suturing system in minimally invasive endoscopic procedures: overview of its safety and efficacy and comparison to oversticthTM
Published in Expert Review of Medical Devices, 2022
Tara Keihanian, Mohamed O Othman
Acute, full-thickness defect in the gastrointestinal tract is defined as perforation. Perforation can be iatrogenic in the setting of ulcers, bowel ischemia, inflammatory bowel disease, Boerhaave syndrome, malignancy, or iatrogenic after Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD). There are multiple case reports and case series describing the efficacy of OverStich in closing defects in the esophageal, gastric, small, and large bowel mucosal defects.