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Intracellular Redox Status and Disease Development: An Overview of the Dynamics of Metabolic Orchestra
Published in Jyoti Ranjan Rout, Rout George Kerry, Abinash Dutta, Biotechnological Advances for Microbiology, Molecular Biology, and Nanotechnology, 2022
Sharmi Mukherjee, Anindita Chakraborty
In the case of PD, increased ROS levels promote auto-oxidation of dopamine, causing neuromelanin formation, proteasomal impairment, modification of α-synuclein, oligomerization, and fibrillization. Consequently, this causes dopaminergic neuron degeneration in the substantia nigra of the concerned patients (Chen et al., 2012; Herrera et al. 2005). Increased oxidative stress is also associated with restricting enzyme activities, oxidative deamination of primary monoamine oxidase, peroxidation of the mitochondrial cardiolipin, cytochrome c release from mitochondria causing neurotoxicity and cell death (Singh et al., 2019).
Nanotherapeutics: Enabling Vitamin D3 as a Multifaceted Nutraceutical
Published in Bhupinder Singh, Minna Hakkarainen, Kamalinder K. Singh, NanoNutraceuticals, 2019
Krantisagar S. More, Vinod S. Ipar, Amit S. Lokhande, Anisha A. D’souza, Padma V. Devarajan
Parkinson’s disease is characterized by substantial loss of dopaminergic neurons. These dopaminergic neurons are protected by glial cell derived neurotrophic factor (GDNF), which prevents loss of dopamine neurotransmitter and also increases Tyrosine to L-dopa conversion. It has been reported that vitamin D increases the neurotrophic factors such as GDNF in the substratum nigra or striatum, and also protects dopaminergic neurons from cell death when exposed to toxic agents. Thus, vitamin D has a therapeutic role in Parkinson’s disease (Knekt et al., 2010; Lương and Nguyễn, 2012; Mpandzou et al., 2016).
Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathology and dys-regulations of Dopamine and Glutamate in rat brain
Published in Journal of Environmental Science and Health, Part A, 2023
Adelaja Akinlolu, Victor Emojevwe, Raphael Uwejigho, Juliet Ilesanmi, Rokibat Owolabi, Abimbola Igandan
Dopamine is involved in regulations of arousal, motor control, motivation, reinforcement, reward, sexual gratification, learning and memory, nausea and lactation.[21] Dopaminergic neurons are mainly found in the arcuate nucleus of hypothalamus, ventral tegmental area of the midbrain and substantia nigra pars compact.[22] In addition, the loss of Dopaminergic neurons is associated with pathogenesis of neurodegenerative diseases such as Parkinson’s disease (PD).[23]