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Role of Metals in Neurodegeneration
Published in Debasis Bagchi, Manashi Bagchi, Metal Toxicology Handbook, 2020
Abhai Kumar, Smita Singh, Rameshwar Nath Chaurasia
The metal poisoning occurrence in patients needs to transfer the patient from exposing environment followed by gastrointestinal decontamination. The Mn concentration decreases rapidly in blood of children with cholestasis receiving parental nutrition after discontinuation of Mn supplementation (58). The patients with chronic metal exposure which accumulates in the nervous system, bone, and other tissue rather than plasma need better therapeutic approach to prevent from metal-induced chronic damage. Currently, chelation therapy is a common treatment to remove additional metals in the body for both chronic and acute metal poisoning. Chelators include British antilewisite (BAL), succimer (DMSA), Prussian blue, calcium disodium edetate (CaNa2EDTA), and D-Penicillamine (Cuprimine). The chelators have the negative effects on the body, such as headache, fatigue, renal failure, nasal congestion, gastrointestinal side effects, and life-threatening hypocalcemia; the concentration and dosage of these chelators are the major concern when performing chelation therapy. The exporter of specific metal such as SLC30A10 which is newly identified Mn transporter facilitate in the efflux of excessive intracellular Mn in a patient with dystonia, parkinsonism, hypermanganesemia, and manganism (59). Future studies to identify metal-specific transporters are in great need to design therapeutics to treat metal-induced toxicity.
Restricted substances for textiles
Published in Textile Progress, 2022
Arun Kumar Patra, Siva Rama Kumar Pariti
Diagnosis of heavy metal poisoning is normally done through blood and urine tests, hair and tissue analysis or X-ray imaging. Treatment is usually carried out in the form of chelation therapy, where a suitable chelating agent specific to the metal involved is given either orally, intramuscularly or intravenously. The chelating agent encircles and binds the metal in the body and releases it through the excretory system. However the treatment can be painful and it is not possible to reverse any neurological damage that has already occurred (Wakankar, 2013). Some of the heavy metals are individually discussed below.
Effect of chelation therapy on arrhythmogenic and basal ECG parameters of lead exposed workers
Published in Archives of Environmental & Occupational Health, 2022
Mustafa Karanfil, Meşide Gündüzöz, Murat Karakurt, Emre Aruğaslan, Mustafa Bilal Özbay, Sefa Ünal, Kürşat Akbuğa, Ahmet Akdi, Mehmet Akif Erdöl, Ahmet Göktuğ Ertem, Çağrı Yayla, Özcan Özeke
Chelation therapy is also used for cardiovascular disease treatment. The effect of chelation therapy on cardiovascular system is controversial. There are contradictory data on literature.44,45 Possible mechanism advocated about the effect on cardiovascular system are decalcification of coronary plaques, decreasing platelet aggregation and free oxygen radicals, vasodilation, effect on parathormone, lipid and iron metabolism.46–48 We do not have enough data about the effect of chelation on ECG parameters.