China 
Africa 
Explore chapters and articles related to this topic
Preservatives and Why They Are Useful
Published in Jeanne Moldenhauer, Disinfection and Decontamination, 2018
It is believed that this effect may be a result of effects on the membrane potential, membrane enzymatic function or a generalized membrane permeability. The preservatives cetrimide, chlorhexidine, hexachlorophene, 2-penoxyethanol, parabens, and phenols all affect the membrane permeability. They allow the “leaking” of essential cell constituents that in turn results in the cell dying. Sorbic acid works to inhibit the transport mechanisms across the cytoplasmic membrane and suppressed fumarate oxidation. The preservative chlorhexidine inhibits the enzyme ATPase. This results in the inhibition of cellular anaerobic activity. If the preservative concentrations are elevated it causes the precipitation of cytoplasmic nucleic acids and related proteins. The biguanide preservatives cause phase separation and the formation of domains in the phospholipid bi-layer. The chelating agents like edetic acid (EDTA) affect the cytoplasmic membranes integrity as it chelates the divalent calcium and magnesium ions, and thus the ions are unavailable to the microbial cell and other antimicrobial agents. The quaternary ammonium compounds used as preservatives bind strongly to the cytoplasmic membrane resulting in general damage to the membrane and subsequent leaking. They particularly target the phospholipid bi-layer (Elder and Crowley, 2012).
Influences of alcohol/polyols on interaction of moxifloxacin hydrochloride through cetyltrimethylammonium bromide at numerous temperatures and compositions
Published in Molecular Physics, 2021
Zahirul Islam Chowdhury, Javed Masood Khan, Shahed Rana, Shamim Mahbub, Md. Farhad Hossain, Mohammad Majibur Rahman, Mohammad Irfan, Mohammad Z. Ahmed, Md. Anamul Hoque, SK Jahir Anwar
The cetyltrimethylammonium bromide [CTAB; Scheme 2], the prime component of cetrimide antiseptic dermal medicine, is a quaternary ammonium salt that holds the capability to function as an energetic therapeutic agent in treating human cancer, most particularly, for head and neck cancer. The CTAB is also described to be utilised in the denaturation of proteins, DNA extraction, and other domestic applications.