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The effect of experimentally-induced diabetes on rat hippocampus and the potential neuroprotective effect of Cerebrolysin combined with insulin. A histological and immunohistochemical study
Published in Egyptian Journal of Basic and Applied Sciences, 2023
Doaa El-Adli, Salwa A. Gawish, Amany AbdElFattah Mohamed AbdElFattah, Mona Fm. Soliman
Cerebrolysin has the ability to penetrate BBB. Cbl plays an important role in the continuous protection against neurodegeneration via neurotrophic factor and Shh (sonic hedgehog) signaling pathways. Also, neurotrophic and nerve growth factors in its composition promote cell division cycle and act as anti-oxidants [12]. This may explain the microscopic findings in Group IV.