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Nanoemulsions: Status in Antimicrobial Therapy
Published in Adwitiya Sinha, Megha Rathi, Smart Healthcare Systems, 2019
Atinderpal Kaur, Rakhi Bansal, Sonal Gupta, Reema Gabrani, Shweta Dang
Respiratory infection is the major infection in patients suffering from cystic fibrosis. Among the various microorganisms responsible for respiratory infection, Burkholderia cepacia complex is the most harmful in cystic fibrosis (LiPuma, 2001), as it is among the most antimicrobial-resistant microorganisms. LiPuma et al. (2009) investigated the antibacterial activity of NE against 150 bacterial isolates recovered from cystic fibrosis (CF) respiratory tract specimens. The growth of all selected strains was inhibited by NE with minimum inhibitory concentration (MIC50) of 1.2 μg/mL and MIC90 of 125 μg/mL. NB-401 was more active against non-Burkholderia strains than Burkholderia strains. NE was thus effective in treating respiratory infections related to cystic fibrosis.
Burkholderia cepacia Complex (BCC) in Your Facility
Published in Jeanne Moldenhauer, Disinfection and Decontamination, 2018
BCC is an abbreviation of Burkholderia cepacia complex. Microbewiki defines this term as, “Burkholderia cepacia complex is a group of Gram-negative, non-spore-forming bacilli that are composed of approximately 17 closely-related species which are grouped into nine genomovars” (Microbewiki, 2017). Another definition says, “Burkholderia cepacia complex, or simply Burkholderia cepacia, is a group of catalase-producing, lactose-nonfermenting, Gram-negative bacteria composed of at least 20 different species, including B. cepacia, B. multivorans, B. cenocepacia, B. vietnamiensis, B. stabilis, B. ambifaria, B. dolosa, B. anthina, B. pyrrocinia and B. ubonensis. B. cepacia is an opportunistic human pathogen that most often causes pneumonia in immunocompromised individuals with underlying lung disease. Patients with sickle-cell haemoglobinopathies are also at risk. The species also attacks young onion and tobacco plants, as well as displaying a remarkable ability to digest oil” (Wikipedia, 2017).
Characterization of Burkholderia cepacia complex from environment influenced by human waste
Published in International Journal of Environmental Health Research, 2022
Jasna Hrenovic, Martina Seruga Music, Martina Drmic, Lucija Pesorda, Branka Bedenic
The Burkholderia cepacia complex (BCC) is a group of gram-negative nonfermentative bacteria that currently includes 21 closely related species (CLSI 2019; EUCAST 2021). The members of BCC were firstly described by Burkholder in 1950 as plant pathogen (Burkholder 1950). Further, the BCC were commonly reported in plant rhizosphere, soli and freshwater mud (Miller et al. 2002). From 1980s the BCC are more often reported as opportunistic pathogen in immunocompromised patients (Isles et al. 1984). The BCC, with B. multivorans and B. cenocepacia as predominant species, is known as a cause of chronic respiratory infection among patients suffering from cystic fibrosis (CF), but infect also the non-CF patients. Both sporadic infections and hospital outbreaks express a wide range of clinical manifestations (Mahenthiralingam et al. 2005).