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Peptide-Based Drug Delivery Systems: Future Challenges, Perspectives, and Opportunities in Nanomedicine
Published in Shaker A. Mousa, Raj Bawa, Gerald F. Audette, The Road from Nanomedicine to Precision Medicine, 2020
Diego Tesauro, Antonella Accardo, Carlo Diaferia, Vittoria Milano, Jean Guillon, Luisa Ronga, Filomena Rossi
Integrins are heterodimers transmembrane receptors related to the cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. Integrins are one of the most important receptors that can be used in active targeting strategies [122]. Among the different subfamilies of these heterodimeric transmembrane proteins, integrins αvβ3 and αvβ5 have prominent roles in angiogenesis and metastatic disseminations. The integrin αvβ3 plays a very domineering role in angiogenesis and is overexpressed in endothelial cells of the tumor. Recently a large exploration in the field of αvβ3 integrin-mediated bioactive targeting for cancer treatment has been reported. All designed peptide sequences contain the RGD motif.
Anti-Cancer and Anti-Angiogenic Properties of Nano-Diamino-Tetrac, A Thyroid Hormone Derivative
Published in Shaker A. Mousa, Raj Bawa, Gerald F. Audette, The Road from Nanomedicine to Precision Medicine, 2020
Paul J. Davis, Shaker A. Mousa
Concentration of the αvβ3 integrin in tumor cells and proliferating blood vessels makes the protein a potentially attractive target for imaging of tumors or nonmalignant highly vascular lesions, e.g., localized infection or occult sites of systemic inflammatory diseases. Kang and co-workers have tested radiolabeled tetrac conjugated to liposomes for preclinical PET imaging of tumors and tumor angiogenesis [90]. This modality provided modestly heightened tumor signal above background, but the uptake of liposomes by liver and spleen and by other normal tissues imposed a noise-to-tumor signal relationship that was undesirably high. Others have used radiolabeled RGD compounds for preclinical tumor imaging [91] and the topic of PET imaging of integrins has recently been reviewed [92].
Peptide-Based Drug Delivery Systems: Future Challenges, Perspectives, and Opportunities in Nanomedicine
Published in Shaker A. Mousa, Raj Bawa, Gerald F. Audette, The Road from Nanomedicine to Precision Medicine, 2019
Diego Tesauro, Antonella Accardo, Carlo Diaferia, Vittoria Milano, Jean Guillon, Luisa Ronga, Filomena Rossi
Integrins are heterodimers transmembrane receptors related to the cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. Integrins are one of the most important receptors that can be used in active targeting strategies [122]. Among the different subfamilies of these heterodimeric transmembrane proteins, integrins αvβ3 and αvβ5 have prominent roles in angiogenesis and metastatic disseminations. The integrin αvβ3 plays a very domineering role in angiogenesis and is overexpressed in endothelial cells of the tumor. Recently a large exploration in the field of αvβ3 integrin-mediated bioactive targeting for cancer treatment has been reported. All designed peptide sequences contain the RGD motif.
‘Borono-lectin’ based engineering as a versatile platform for biomedical applications
Published in Science and Technology of Advanced Materials, 2018
Akira Matsumoto, Yuji Miyahara
Bandyopadhyay and Gao have made use of this chemistry as a means to accomplish peptide cyclization [105]. There is a growing interest in the synthesis of cyclic peptides mimicking the structure and function of their natural counterparts. Among a number of the peptide cyclization strategies, the disulfide chemistry represents so far the only non-permanent or reversible type of linkages enabling the design of ‘smart’ peptides that can turn on or off their activity in response to biological stimuli. Gao et al. demonstrated that iminoboronate linkages could also play this role. In particular, a series of RGD (an integrin-recognition motif) containing sequences bearing artificial boronate-functionalized amino acid moieties in a way flanking the above were designed and optimized so as to spontaneously yield mono- or bicyclizations via intramolecular iminoboronate formation (Figure 9). The iminoboronate linkages incorporated into these peptides were reversibly cleavable in response to acidification, oxidation, and addition of some exogenous small molecule modulators. Furthermore, fluorescence-labeled version of the iminoboronate-cyclized RGD peptides were tested for the binding with SKOV3 cells, an ovarian cancer cell line known to overexpress the αvβ3 integrin. As expected, the fluorescence staining of the cells was effectively switched when altering the pH between 7.4 and 6.0, under which the peptide undergoes conformational change between cyclized and linearized states.
Buthionine sulfoximine and chemoresistance in cancer treatments: a systematic review with meta-analysis of preclinical studies
Published in Journal of Toxicology and Environmental Health, Part B, 2023
Camila dos Reis Oliveira, Joedna Cavalcante Pereira, Andressa Barros Ibiapina, Italo Rossi Roseno Martins, João Marcelo de Castro e Sousa, Paulo Michel Pinheiro Ferreira, Felipe Cavalcanti Carneiro da Silva
Rodríguez-Gómez et al. (2014) examined mice treated with BSO prior to tumor induction and in combination with TETRAC (αvβ3 integrin receptor inhibitor) to assess tumor growth angiogenesis and aminopeptidase activity in Lewis lung cells. The animals drinking water with 10 mM BSO for 28 days exhibited a significant decrease in tumor mass and total hemoglobin content. Further, BSO produced significant rise in GluAp and AlaAP activity, in addition to diminishing vascular endothelial growth factor (VEGF) receptors in tumors. In this scenario, the combination of BSO and with TETRAC induced greater reduction in tumor mass compared to TETRAC alone (Rodríguez-Gómez et al. 2014).
A review on magnetic polymeric nanocomposite materials: Emerging applications in biomedical field
Published in Inorganic and Nano-Metal Chemistry, 2023
Promising outcomes have been recorded related to the detection sensitivity and delimitation of pathological structures, such as cerebral tumors or metastatic tumors, inflammation, and ischemia.[258] For this purpose, peptides or antibodies that specifically bind to receptors overexpressed in tumor cells, such as MUC-1, αvβ3 integrin, EGFR, HER2/neu, uPAR, and prostate specific membrane antigen, were incorporated into iron oxide composites leading to a targeted accumulation in the pathological tissues and enhancing also T2 contrast for MRI detection.[259]