Degenerative Diseases of the Nervous System
Philip B. Gorelick, Fernando D. Testai, Graeme J. Hankey, Joanna M. Wardlaw in Hankey's Clinical Neurology, 2020
Other medical conditions must be ruled out in order to make a diagnosis of AD, including those that may cause reversible encephalopathy. The following serum tests should be obtained: Complete blood count plus platelets.Comprehensive metabolic panel.Thyroid-stimulating hormone.Vitamin B12.Rapid plasma reagin (RPR) and HIV serology, for those with appropriate risk factors.Thiamine and folate, for those with appropriate risk factors.
Pulmonary sarcoidosis
Muhunthan Thillai, David R Moller, Keith C Meyer in Clinical Handbook of Interstitial Lung Disease, 2017
There are no diagnostic blood tests for sarcoidosis. Consensus recommendations for an initial evaluation include a complete blood count and comprehensive metabolic panel with liver, kidney function and calcium levels (1). A urinalysis, electrocardiogram and ophthalmologic exam are also recommended. The serum angiotensin-converting enzyme lacks the specificity and sensitivity to serve as a diagnostic test or clinical biomarker and is not used in all centres. Serologic testing for rheumatologic conditions, vasculitis, infectious and other chronic inflammatory disorders may be helpful in distinguishing competing diagnoses. Specific organ testing (e.g. cardiac, neurologic) is indicated on a case-by-case basis when symptoms or manifestations suggest these organs may be involved (discussed in Chapter 16).
Lifestyle Medicine Clinical Processes
James M. Rippe in Lifestyle Medicine, 2019
Basic laboratory evaluations that would be of value in identifying and tracking baseline risk for metabolic disease and preventable lifestyle-related chronic illness include the following:Comprehensive Metabolic PanelComplete Blood CountFasting Lipidshs C-reactive proteinTSH, Free T4Vitamin DFasting blood sugarGlycosylated Hemoglobin
Asymptomatic ventricular fibrillation in peripartum cardiomyopathy with a left ventricular assist device
Published in Baylor University Medical Center Proceedings, 2021
Elie P. Dib, Paul A. Grayburn, Amarinder Bindra
A 43-year-old woman presented to the hospital with complaints of multiple shocks from her defibrillator. She reported no warning symptoms beforehand and denied palpitations, lightheadedness, and presyncope. Although she had known peripartum cardiomyopathy and stage D chronic systolic heart failure, she was not a candidate for heart transplant due to adverse socioeconomic circumstances. Her ejection fraction was 15% with a Heartware LVAD and a history of recalcitrant right ventricular failure on sildenafil. Vital signs could not be obtained due to pulselessness. She was in no distress, lying flat comfortably. Her extremities were warm and dry. A Heartware hum was present, and overt jugular vein distention was noted. The comprehensive metabolic panel was essentially normal. An international normalized ratio of 5.8 and a brain natriuretic peptide level of 373 pg/mL were the only notable laboratory results.
Effects of Hemp Extract on Markers of Wellness, Stress Resilience, Recovery and Clinical Biomarkers of Safety in Overweight, But Otherwise Healthy Subjects
Published in Journal of Dietary Supplements, 2020
Hector L. Lopez, Kyle R. Cesareo, Betsy Raub, A. William Kedia, Jennifer E. Sandrock, Chad M. Kerksick, Tim N. Ziegenfuss
For screening purposes, blood collected at visit one was analyzed for a comprehensive metabolic panel, complete blood count with platelet differentials, and lipid panel. Components of the comprehensive metabolic panels consists of glucose, blood urea nitrogen [BUN], creatinine, aspartate aminotransaminase [AST], alanine aminotransaminase [ALT], creatine kinase, lactate dehydrogenase, total bilirubin, alkaline phosphatase [ALP], uric acid, sodium, potassium, total protein, albumin, globulin, and iron. Complete blood counts were analyzed for absolute and percentage of contribution for neutrophils, eosinophils, basophils, lymphocytes, and monocytes in addition to overall white blood cell and red blood cell count, hemoglobin, hematocrit, mean corpuscle volume, mean corpuscle hemoglobin, red cell dimension width, and mean corpuscle hemoglobin content. Lipid panel components consist of triglycerides [TG], total cholesterol [TC], LDL cholesterol, HDL cholesterol. All analyses were completed using automated clinical chemistry analyzers (LabCorp, Dublin, OH branch). Additionally, serum levels of chromogranin-A were assessed by LabCorp using the ThermoFisher/BRAHMS KRYPTOR® time resolved amplified cryptate emission (TRACE) between energy donor and acceptor in a sandwich immunofluorescent assay using two mouse monoclonal antibodies (van der Knaap et al. 2015). All samples from the same day were batch analyzed with test-retest reliabilities commonly reported using internal quality control data from clinical laboratories and associated automated analyzers within a range of 3 – 5% (Cuka et al. 2001).
Stiff-person syndrome: an atypical presentation and a review of the literature
Published in Hospital Practice, 2021
Benjamin C. Lin, Jaspreet Johal, Keithan Sivakumar, Alissa E. Romano, Hussam A. Yacoub
Basic laboratory studies included a complete blood count and a comprehensive metabolic panel which were within normal limits. Other pertinent laboratory work-up included a serum vitamin B12 of 303 pg/mL (normal: >200 pg/mL), thyroid stimulating hormone level of 0.60 uIU/mL (normal range: 0.36–3.74 uIU/mL), erythrocyte sedimentation rate of 23 mm/hr (normal range: 0–30 mm/hr), C-reactive protein level of <3.0 mg/L (normal: <7.0 mg/L), and creatine phosphokinase of 607 U/L (normal: <201 U/L). Further laboratory work-up for antinuclear antibody (ANA), angiotensin converting enzyme, aldolase, copper, heavy metals, and serum protein electrophoresis (SPEP) was unremarkable. Furthermore, antibodies for acetylcholine receptor, anti-signal recognition particle, ganglioside, HMG-CoA reductase, Lyme disease, muscle-specific kinase, Sjorgen’s syndrome, and voltage-gated potassium and calcium channels were within normal limits. Serum and cerebrospinal fluid (CSF) paraneoplastic panel, including amphiphysin and glutamic acid decarboxylase (GAD) antibodies, were unremarkable. CSF analysis including cell counts, infectious work-up, and flow cytometry was unrevealing. Computed tomography of the chest, abdomen, and pelvis as well as magnetic resonance imaging of the brain, cervical, thoracic, and lumbar spine were unremarkable. The patient also underwent an electromyography (EMG) which showed significant peroneal motor neuropathy and complex repetitive discharges in the left tibialis anterior muscle.
Related Knowledge Centers
- Basic Metabolic Panel
- Current Procedural Terminology
- Screening
- Liver
- Kidney
- Test Panel
- Blood Test
- Electrolyte
- Fluid Balance
- Physical Examination