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pushing children into suicide with happy pills
Published in Peter C. Gøtzsche, Richard Smith, Drummond Rennie, Deadly Medicines and Organised Crime, 2019
Peter C. Gøtzsche, Richard Smith, Drummond Rennie
The pervasive scientific misconduct has distorted seriously our perception of the benefits and harms of SSRIs. As an example, a 2004 systematic review showed that, when unpublished trials were included, a favourable risk–benefit profile changed to an unfavourable one for several of the SSRIs.27 Also in 2004, a researcher used the full reports of Glaxo’s trials that were made available on the internet as a result of litigation, and he found in his meta-analysis that paroxetine increased significantly suicidal tendencies, odds ratio 2.77 (95% confidence interval 1.03 to 7.41).14 He included three trials, among them the unpublished study 377, which didn’t show that paroxetine was better than placebo (Glaxo had stated in an internal document that ‘There are no plans to publish data from Study 377.’)28He also included the infamous study 329. He described that an 11-year-old boy who threatened to harm himself and was hospitalised was coded as a case of exacerbated depression, and that a 14-year-old boy who had harmed himself and expressed hopelessness and possible suicide thoughts and was hospitalised was coded as a case of aggression.
A proportional hazard cure model for ordinal responses by self-modeling regression
Published in Journal of Applied Statistics, 2018
Aliakbar Mastani Shirazi, Aluisio Pinheiro
In the U.S. National Institute of Mental Health (NIMH) Schizophrenia Collaborative Study, 329 patients were randomly assigned to receive one of four medications: placebo, chlorpromazine, fluphenazine or thioridazine; the latter three medications are anti-psychotic drugs. The study protocol called for longitudinal measurements to be made at weeks 0, 1, 3 and 6. The outcome variable of interest is a 4-level ordinal scale measuring ‘severity of illness’, derived from item 79 of the Inpatient Multidimensional Psychiatric Scale [10]. The four categories of the ordinal response correspond to: 1 = normal or borderline mentally ill, 2 = mildly or moderately ill, 3 = markedly ill and 4 = severely or among the most extremely ill. We consider the schizophrenia data to illustrate application of the SI-PHC model.
Development and validation of the family management scale for children with asthma (FMSCA)
Published in Journal of Asthma, 2020
Yana Xing, Xiqian Gu, Zhenzhen Wei, Wei Zhang, Sharron J. Crowder, Hongmei Duan
Table 1 presents the demographic information of the sample. A total of 345 preliminary scales were given out for the study, 329 eligible scales were returned (response rate 95.4%). The average age of the 329 children with asthma was 7.19 years (SD = 2.73), 72% were boys and 28% were girls. Among the corresponding 329 parents, 92 fathers (28%) with a mean age of 37.59 years and 237 mothers (72%) with a mean age of 35.86 years.
Pathology Reports: Discrepancy Patterns of Second Opinions in a Referral Cancer Center
Published in Cancer Investigation, 2023
Shirin Taraz Jamshidi, Masoumeh Gharib, Mohammad Etemadi, Lida Jarahi, Sare Hosseini, Mona Ariamanesh, Mansoureh Dehghani
In this study, 329 cases (94%) were referred by a physician (whether surgeon or oncologist) for a second opinion and only 5 (1.4%) by a pathologist. The remaining 16 cases (4.6%) referred themselves, seeking second opinion (Figures 1–3, Table 1).