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Instability of Human Mitochondrial DNA, Nuclear Genes and Diseases
Published in Shamim I. Ahmad, Handbook of Mitochondrial Dysfunction, 2019
The last element to discuss is mtSSB – single strand binding protein. It functions as a tetramer and stimulates polymerase gamma activity. It was shown that the amount of mtSSB directly correlates with mtDNA copy number23. Moreover, lack of mtSSB is lethal in a Drosophila melanogaster model24. The protein is encoded by the SSBP gene (7q34) but until now no pathogenic variants in it have been described.
Role of telomeres and telomerase in aging and cancer
Published in J. K. Cowell, Molecular Genetics of Cancer, 2003
Jerry W. Shay, Woodring E. Wright, Roger A. Schultz
The gene responsible for WS (WRN) has been cloned and encodes a protein with homology to the E. coli RecQ (Yu et al., 1996). The RecQ protein binds single-stranded DNA and has a 3’→5’ helicase activity (Umezu et al., 1990). That helicase function is dependent on ATP hydrolysis and is stimulated (> 100 fold) by single strand binding protein (Umezu and Nakayama, 1993). RecQ can resolve a wide variety of substrates including recombinational joint molecules generated by RecA protein (Harmon and Kowalczykowski, 1998). These properties of RecQ led to the suggestion that it may improve the fidelity of recombination by dissociating illegitimate recombination events that are initiated through microhomology. Reintroduction of the WRN gene into WS cells complements the premature senescence phenotype of WS cells (Hisama et al., 2000). Similarly, introduction of an exogenous hTERT gene into WS cells yields suppression of senescence of WS cells, as it does for most other cell types tested (Ouellette et al., 2000; Wyllie et al., 2000). Another report indicates that the introduction of hTERT gene into WS cells can render partial correction of the 4NQO sensitivity of those cells (Hisama et al., 2000). This suggests that the 4NQO sensitivity is intimately linked to telomere length.
Correlation between shock index and postoperative outcomes for patients undergoing on-pump coronary artery bypass graft surgery (an observational study)
Published in Egyptian Journal of Anaesthesia, 2023
Ahmed Said, Maged Salah, Marwa Samir, Rami Magdy
Birkhahn et al. enrolled 46 healthy blood donor volunteers to do a controlled blood loss of 450 ml as a simulation for early acute hypovolemia. They found that SI in early acute blood loss had increased above the normal range; meanwhile, there was no apparent increase above the accepted normal range in the HR nor decrease below the normal range in SBP, so SI was found to be superior in identifying patients with early acute hemorrhage than HR and sSBP [11].
A randomized controlled comparison of three modes of ventilation during cardiopulmonary bypass on oxygenation in pediatric patients with pulmonary hypertension undergoing congenital heart surgeries
Published in Egyptian Journal of Anaesthesia, 2022
Ahmed Ali Gado, Salwa Mohamed Hefnawy, Ashraf M Abdelrahim, Mostafa Abdel Wahab Abdel Aziz Alberry, Mai A. El Fattah Madkour
We investigated the effect of different ventilation modes during cardiopulmonary bypass for patients undergoing corrective surgeries for intra-cardiac defects. There were no significant differences between the three groups regarding PASP, PASP/SSBP, the demographic characteristics, the clinical outcomes (Hospital stay, ICU stay, ventilator-dependent time), and the need for isotopes.
Graphene nano-ribbon based high potential and efficiency for DNA, cancer therapy and drug delivery applications
Published in Drug Metabolism Reviews, 2019
Seyyed Mojtaba Mousavi, Sadaf Soroshnia, Seyyed Alireza Hashemi, Aziz Babapoor, Younes Ghasemi, Amir Savardashtaki, Ali Mohammad Amani
The nano carrier ability was observed by PEI-g-GNR protecting locked nucleic acid modified Molecular beacon (LNA-m-MB) from nuclease digestion or single-strand binding protein interaction, the high charge density of PEI, and the large surface area of GNRs.