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Football and healthy ageing
Published in Peter Krustrup, Daniel Parnell, Football as Medicine, 2019
Pasqualina Buono, Jesper L. Andersen, Andreina Alfieri, Annamaria Mancini, Stefania Orrù, Marie Hagman, Peter Krustrup
Very recently, it has been demonstrated that lifelong football training positively affects the expression of genes and proteins involved in auto-lysosomal and proteasome (RAD23A, HSPB6, RAB1B, TRAP1, SIRT2 and HSBPB1, in cell growth and differentiation (RPL1, RPL4, RPL36, MRLP37) and in autophagy pathways (Bcl-2, HSP70, HSP90, PSMD13 and ATG5-ATG12 protein complex) in skeletal muscle of football-trained veterans compared to age-matched untrained elderly subjects. These results suggest that lifelong football training promotes skeletal muscle longevity (Mancini et al. 2019).
Comprehensive DNA repair gene expression analysis and its prognostic significance in acute myeloid leukemia
Published in Hematology, 2021
Sholhui Park, Yi-Jun Kim, Hee Jin Huh, Hae-Sun Chung, Miae Lee, Young Mi Park, Yeung Chul Mun, Chu-Myong Seong, Jungwon Huh
Concerning karyotypic subgroups in this study, higher expression of the APEX1, PARP1, RAD23A, RAD23B, MSH2, POLD3, and FEN1 genes was observed in patients with complex karyotype, while AML with normal karyotype showed more downregulation of RAD23B than the other karyotypic subgroups (Supplemental Figure 2). Although the exact roles of RAD23A and RAD23B have not yet been elucidated in AML, RAD23 complexed with XPC recognizes UV-induced DNA distortion and leads to successive DNA repair through the NER pathway [30,31]. According to one study, upregulation of DNA repair genes associated with DSB repair and cell cycle checkpoint signaling genes was observed in AML with a complex karyotype [17]. Another study showed that PARP1 and LIG3 were upregulated in patients with chromosomal translocation [32]. Taken together, increased DNA repair gene expression could be a distinct characteristic in AML with a complex karyotype [17,33,34].