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Golgi apparatus regulation of differentiation
Published in C. Yan Cheng, Spermatogenesis, 2018
Louis Hermo, Regiana L. Oliveira, Charles E. Smith, Catherine E. Au, John J. M. Bergeron
Early evidence of abnormalities of acrosome formation was noted for the blind-sterile (bs) autosomal recessive mutation in mouse that results in male sterility. This is caused by mutations in the Tbc1d20 gene, which encodes a GTPase-activating protein specific for RAB1 and RAB2 small GTPase families.155 Sterile bs/bs males exhibit reduced testis weights and few epididymal sperm that when present reveal morphologically aberrant head shapes. The most striking effect of the bs mutation is the failure of acrosome formation during spermiogenesis with disorganized proacrosomic granules being detected and no evidence of a single acrosomal cap or fully developed acrosome.156
The SAS Genes: Functionally Distinct Members of the YPT1/SEC4 Family in Dictyostelium
Published in Juan Carlos Lacal, Frank McCormick, The ras Superfamily of GTPases, 2017
Alan R. Kimmel, Tracy Ruscelli, James Cardelli
In a collaborative effort the laboratories of J. Cardelli and G. Weeks have isolated cDNAs for 23 additional members of the ras superfamily of GTPases from Dictyostelium. New cDNAs have been identified that encode: (1)8 members of the rho family, including a racl homolog; (2) 11 members of the rab family, including potential homologs to rab1, rab2, rab4, rab7, and rabil; (3) 3 members of the ras family; and (4) a potential ranlTC4 homolog.
Novel therapeutic strategies for stroke: The role of autophagy
Published in Critical Reviews in Clinical Laboratory Sciences, 2019
Seyed Fazel Nabavi, Antoni Sureda, Ana Sanches-Silva, Kasi Pandima Devi, Touqeer Ahmed, Momina Shahid, Eduardo Sobarzo-Sánchez, Marco Dacrema, Maria Daglia, Nady Braidy, Rosa Anna Vacca, Ioana Berindan-Neagoe, Diana Gulei, Davide Barreca, Maciej Banach, Seyed Mohammad Nabavi, Ahmad Reza Dehpour, Samira Shirooie
In yeast, the transition from initiation to nucleation is determined by the intervention of scaffold proteins, such as transport protein particle III (TRAPPIII) and a Rab1 family GTPase called Ypt1/RAB1 in mammals. Their task is to deliver the Atg9 vesicle and coat protein complex II (COPII) to induce the next phase of autophagy [37,38]. In mammals, this event drives the formation of the PI3K complex III, which consists of UV irradiation resistance-associated tumor suppressor gene (UVRAG/Vsp38 in yeast), Beclin-1 (BECN-1/Vps30-Atg6 in yeast), and myristylated kinase (VPS15, p150/Vps15 in yeast). This complex allows the phosphorylation of its catalytic subunit VPS34, inducing the production of phospatidylinositol-3-phospate (PtdIns3P), which plays a substantial role in the elongation of the phagophore and the recruitment of additional Atg proteins to the phagophore [30,39].