LAIR1

LAIR1

LAIR1 is a type of inhibitory receptor that is important for regulating immune responses. It is expressed on various immune cell subsets, including T cells, NK cells, monocytes, macrophages, and dendritic cells. LAIR1 has a single IgSF extracellular domain with no known ligands and its intracytoplasmic domain contains two YxxL/V motifs.From: The Antibodies [1999], Cancer immunotherapy based on blocking immune suppression mediated by an immune modulator LAIR-1 [2020]

Fc Receptors

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Published in Maurizio Zanetti, J. Donald Capra, The Antibodies, 1999

Marc Daëron

Finally, Leucocyte-Associated Ig-like Receptors-1 (LAIR-1), that are possibly related to ILTs, gp49B1 and KIRs, were described on NK cells, B cells, T cells, fetal thymocytes and monocytes. LAIR-1 have a single IgSF extracellular domain with no known ligands and their intracytoplasmic domain contains two YxxL/V motifs. They could inhibit NK cell cytotoxicity induced via the NK cell receptor, FcγRIIIA, CD2, CD69 or αDNAM-1 [307].

Cancer immunotherapy based on blocking immune suppression mediated by an immune modulator LAIR-1

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Published in OncoImmunology, 2020

Lijun Xu, Shanlong Wang, Jufeng Li, Jie Li, Bingyu Li

Inhibitory receptors containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs) play an important role in the regulation of the immune system.1 These receptors contain ITIM motifs in their intracellular domains and are classified as inhibitory receptors because these motifs can recruit phosphatases such as SHP-1, SHP-2, and SHIP to negatively regulate cell activation.2 The leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) is a collagen-binding ITIM-bearing inhibitory receptor important for the regulation of immune responses and is expressed on the majority of immune cell subsets, including T cells, NK cells, monocytes, macrophages, and dendritic cells.3–7 LAIR-1 can inhibit the cytotoxic activity of effector T cells upon CD3 cross-linking2,8–10 or antigen stimulation.11 Furthermore, the inhibitory capacity of LAIR-1 in T cell clones correlates to surface expression density.12

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Fc Receptors

Cancer immunotherapy based on blocking immune suppression mediated by an immune modulator LAIR-1