Explore chapters and articles related to this topic
Role of Aromatase Inhibitors (AIs) and Selective Estrogen Receptor Modulators (SERMs) in the Treatment of Uterine Leiomyoma
Published in John C. Petrozza, Uterine Fibroids, 2020
Estrogen dependence is unquestionably the common denominator among uterine leiomyoma, endometriosis, adenomyosis and endometrial polyps. 17-β estradiol (E2) stimulates the growth and maintenance of these uterine and endometrial disorders. Uterine leiomyoma's estrogen dependence is well understood; however, the intricate molecular mechanisms involving cell division under estrogen representation is complicated, to say the least. Decreased apoptosis and increased rate of mitosis-stimulated cell division have been documented under estrogen influence; moreover, progesterone's stimulation of the Kruppel-like transcription factor 11 (KLF11) has been implicated as another of the molecular-mediated effects of E2 as well as progesterone [1–3].
Role of glucocorticoid- and monoamine-metabolizing enzymes in stress-related psychopathological processes
Published in Stress, 2020
Vadim Tseilikman, Eliyahu Dremencov, Olga Tseilikman, Michaela Pavlovicova, Lubica Lacinova, Daniela Jezova
First, MAO is a mitochondrial enzyme, and glucocorticoids control general mitochondrial functions. An example here is glucocorticoid dose-dependent regulation of three key characteristics of mitochondrial function: oxidation level, membrane potential, and calcium holding capacity (Du et al., 2009). Second, MAO activity is dependent on the lipid microenvironment, and the ability of glucocorticoids to regulate mitochondrial lipid peroxidation enables them to modulate MAO activity (Ekstedt & Oreland, 1976; Singer, 1995). Finally, glucocorticoids regulate MAO expression, and it has been established that dexamethasone increased krueppel-like factor 11 (KLF11) mRNA and protein levels in cultured neuronal cells. Over-expression of KLF11 resulted in increases in both the MAO-A mRNA concentration and its enzymatic activity (Grunewald et al., 2012; Harris et al., 2015). MAO activity correlated with the microsomal oxidation phenotype (Tseilikman et al., 2016) and the microsomal oxidation inhibitor proadifen reduced MAO activity in both the brain and liver (Kozochkin et al., 2017).
Radiotherapy in combination with hyperthermia suppresses lung cancer progression via increased NR4A3 and KLF11 expression
Published in International Journal of Radiation Biology, 2019
Beomseok Son, Jaewan Jeon, Sungmin Lee, Hyunwoo Kim, Hyunkoo Kang, HyeSook Youn, Sunmi Jo, BuHyun Youn
Krüppel-like factors (KLFs) are DNA-binding transcription factors with three zinc finger DNA-binding domains and diverse functions. In normal tissues, KLFs regulate key cellular processes such as proliferation, inflammation, and differentiation, whereas they are involved in cell proliferation, apoptosis, and metastasis in cancer (Tetreault et al. 2013). Among them, KLF11 expression is decreased in the colon, kidney, lung, ovary, pancreas, and stomach cancers (Fernandez-Zapico et al. 2003). In particular, a clinical study suggested that promoter methylation of KLF11 gene is significantly increased in NSCLC patients, which implies the importance of KLF11 suppression in NSCLC development (Abdolrezaei Anary et al. 2018). However, how KLF11 facilitates radiohyperthermia-induced NSCLC apoptosis has not been elucidated.