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Nanoparticle-Mediated Small RNA Deliveries for Molecular Therapies
Published in D. Sakthi Kumar, Aswathy Ravindran Girija, Bionanotechnology in Cancer, 2023
Ramasamy Paulmurugan, Uday Kumar Sukumar, Tarik F. Massoud
Babar et al. reported the synthesis of anti-miR-155 encapsulated PLGA nanoparticles using a double emulsion solvent evaporation method [122]. PLGA nanoparticles’ surfaces were modified with cell penetrating peptides (CPP) after loading with anti-miR-155, which upon delivery reduced the growth of pre-B-cell tumors in vivo in mice and appeared as an encouraging therapeutic option for lymphoma and leukemia [122]. The miRNA-10b positively controls breast cancer cell migration and invasion through inhibition of HOXD10 target synthesis, and directly inhibits breast cancer metastasis. Anti-miRNA-10b-loaded poly-L-lysine (PLL-anti-miR-10b) nanoparticles, when administered to MDA-MB-231 breast cancer cells, strongly inhibit the invasive property of cells [123]. The miR-21 is an important player in a majority of cancers. Anti-miR-21 and 5-FU-loaded poly(amidoamine) dendrimer nanoparticles significantly enhanced the cytotoxicity of 5-FU and strongly increased the apoptosis of U251 GBM cells, and the migration ability of tumor cells was significantly decreased [124].
Inhibition of microRNA-10b-5p up-regulates HOXD10 to attenuate Alzheimer’s disease in rats via the Rho/ROCK signalling pathway
Published in Journal of Drug Targeting, 2021
Zhongfan Ruan, Yan Li, Rongzhang He, Xuewei Li
MicroRNAs (miRNAs) have been identified in AD, such as miR-128 [4], miR-10a [5] and miR-29a [6]. MiR-10b is a member of the miR-10 family [7] and it has been reported that miR-10b-5p was implicated in Huntington’s disease [8] and glioma [7], while its role in AD has seldom been studied. Belonging to HOX gene family, HOXD10 is involved in cell differentiation and morphogenesis in embryonic development [9]. Moreover, HOXD10 has been revealed to participate in the processes of glioblastoma [10] and motoneuron defferentiation [11], but the effect of HOXD10 on AD remains to be further investigated. The binding relationship between miR-10b and HOXD10 has been revealed by many previous studies [12–14]. In addition, the Rho/ROCK signalling pathway is an essential signal transduction system within the central nervous system, and is broadly implicated in cell migration, development, differentiation and growth [15]. As reported, the Rho/ROCK signalling pathway was able to inhibit neuronal degeneration [16] and promote neural regeneration [17], and was also involved in the progression of AD [18]. We aimed to evaluate the effects of miR-10b-5p on AD development by targeting HOXD10 with the involvement of the Rho/ROCK signalling pathway. We hypothesised that the inhibited miR-10b-5p may improve ethology and pathology in rat AD models by regulating HOXD10 and the Rho/ROCK pathway