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Immunological Aspects
Published in Yamuna Deepani Siriwardana, Leishmaniasis in Sri Lanka, 2023
However, local study demonstrated high prevalence of HLA-B07 in controls, suggesting a protective tendency, and increased HLA B15 in patients, suggesting susceptibility. However, HLA Bw22, an allele similar to this has been identified as a risk factor and HLA B15 as a protective factor in the new world populations (Lara et al., 1991).
Candidiasis
Published in Rebecca A. Cox, Immunology of the Fungal Diseases, 2020
Judith E. Domer, Emily W. Carrow
In summary, what is clear from these and many other studies is that a high percentage (approximately 80%) of the normal human population has CMI demonstrable with Candida antigens, the best correlation being between cutaneous hypersensitivity in vivo and lymphocyte stimulation in vitro. It is also clear that various disease states can alter CMI, sometimes selectively, so that one or more of the in vivo or in vitro assays become negative, the classic example being the immunologic findings in patients with CMCC. In addition to disease states influencing response to Candida antigens, there is the possibility that within the normal population, high and low responders are determined genetically. Nose et al.,232for example, found a correlation between low responders and the HLA-B15 phenotype and high responders and the HLA-B7 phenotype.
Monoclonal Antibodies to Hla-Dr Antigens
Published in Soldano Ferrone, Chella S. David, Ia Antigens: Man and Other Species, 1982
Unfortunately, both polymorphic monoclonal antibodies numbers 16 (anti-HLA-B15) and 31 (anti-HLA-DR5) lost their activity in culture. Numbers 2 and 18 were further characterized and showed that they recognized two epitopes ofβ2m.31
Lymphoproliferative disorders in patients with rheumatoid arthritis in the era of widespread use of methotrexate: A review of the literature and current perspective
Published in Modern Rheumatology, 2018
In stark contrast to the situation of lymphoma in general, little evidence is available about the genetic susceptibility of patients with RA to LPD. Investigators from Kyoto University reported that there was an association between HLA-B15:11 and EBV-positive LPD in RA patients who were administered MTX [24]. The OR [95% CI] and corrected p values for EBV-positive LPD in RA patients who were administered MTX compared to Japanese healthy controls were 18.2 [5.3–62.3] and 0.0079, respectively, and those compared to RA patients receiving MTX without LPD were 38.2 [3.7–390.0] and 0.024, respectively. To date, there are no other gene association studies about LPD in patients with RA in the literature.
Human leukocyte antigen-G polymorphisms in periodontitis
Published in Acta Odontologica Scandinavica, 2020
Letícia Grando Mattuella, Lisiane Bernardi, Francis Maria Báo Zambra, Milene Borges Campagnaro, Rui Vicente Oppermann, Léder Leal Xavier, José Artur Bogo Chies, Letícia Algarves Miranda
An interesting meta-analysis has not observed a positive nor negative significant association between HLA gene polymorphisms and patients with chronic periodontitis. However, in aggressive patients, a positive significant association was described to HLA-A9 and HLA-B15 polymorphisms, whilst, HLA-A2 and HLA-B5 showed a negative association. It is important to mention that all studies included had Caucasian patients in their sample [4]. These same authors believe that differences between the prevalence of certain bacteria in the subgingival biofilm in different countries and in different ethnic groups may influence the results.
HLA Class I in Egyptian patients with Behçet’s disease: new association with susceptibility, protection, presentation and severity of manifestations
Published in Immunological Investigations, 2019
Mohanad M. Elfishawi, Fatema Elgengehy, Ghada Mossallam, Sally Elfishawi, Mostafa Alfishawy, Abdallah Gad, Imman Mokhtar
In this study, HLA Class-I A*24,A*68,B*15,B*42 and B*51 were found to be associated with Behçet’s disease, while Choukri et al. (2001) and Hamzaoui et al. (2012) have shown an association between Behçet’s and HLA-B51 in the Moroccan and Tunisian population, respectively, with an added association of HLA-B15 in the Moroccan population.