EN2

EN2

Postimplantation diabetic embryopathy

Published in Moshe Hod, Lois G. Jovanovic, Gian Carlo Di Renzo, Alberto de Leiva, Oded Langer, Textbook of Diabetes and Pregnancy, 2018

Ulf J. Eriksson, Parri Wentzel

Using an inbred Sprague Dawley strain (L) with about 20% skeletal malformations when the mother is diabetic and inbred Wistar Furth rats (no diabetes-inducible skeletal malformations), a global gene linkage analysis of the skeletal malformations was performed with microsatellites, a study that yielded strong coupling of the malformations to 7 regions on chromosomes 4, 10, 14, 18, and 19 and a weaker coupling to 14 other loci in the genome; altogether we found loci on 16 chromosomes. Searching for candidate genes within a distance of 10 cM from each microsatellite yielded 18 genes that had been implicated in previous studies of diabetic embryopathy. These genes were involved in embryonic development/morphogenesis (Map1b, Shh, Tgfb3, Vegfa, Dvl2, Nf1, Gsk3b, Gap43, Tgfbr3, Gdf1, Csf1r),308–314 regulation of DNA/RNA metabolism (En2, Brcc3, Tp53),192,308,315–317 regulation of apoptosis (Nol3, Bak1),308 and cellular metabolism (Folr1, Akr1b1).149,168,315

Is Engrailed-2 (EN2) a truly promising biomarker in prostate cancer detection?

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Journal Information

Published in Biomarkers, 2020

Joana Do Carmo Silva, Stepan Vesely, Vojtech Novak, Hana Luksanova, Richard Prusa, Marko Babjuk

EN2 is a transcription factor highly conserved during evolution, with early developmental functions as a regulator of transcription and translation (Morgan 2006, Javed and Langley 2014). In the literature, there are references of EN2 as a possible marker of breast, bladder and ovarian cancer (Morgan et al.2013) as well as a promising urinary marker of prostate cancer with elevated sensitivity and specificity (Morgan et al.2011).

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Postimplantation diabetic embryopathy

Is Engrailed-2 (EN2) a truly promising biomarker in prostate cancer detection?