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Scientific Rationale for the Use of Single Herb Remedies in Ayurveda
Published in D. Suresh Kumar, Ayurveda in the New Millennium, 2020
S. Ajayan, R. Ajith Kumar, Nirmal Narayanan
Fouad et al. (2019) attempted to isolate the bacteria from abscesses in camels and evaluated the antibacterial activity of M. oleifera extracts. Abscess in camels is one of the most important bacterial infections, causing anemia and emaciation. The disk diffusion method and minimum inhibitory concentration were used for the evaluation of the antibacterial activity of M. oleifera extracts against isolated bacteria from camel abscesses. The following bacteria were isolated from the abscesses: Corynebacterium pseudotuberculosis, Corynebacterium ulcerans, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Micrococcus spp., Proteus vulgaris, Citrobacter spp. and Staphylococcus epidermidis. The ethanol extracts of M. oleifera showed pronounced antibacterial activity against all the tested organisms. This shows that M. oleifera can be used for controlling pyogenic bacteria.
The Utility of Immunoglobulin Fusions in DNA Immunization
Published in Maurizio Zanetti, J. Donald Capra, The Antibodies, 2002
Alexandra J. Corbett, Brent S. McKenzie, Robyn M. Sutherland, Jamie L. Brady, Richard A. Strugnell, Stephen J. Kent, David R. Kramer, Jeffrey S. Boyle, Martin J. Pearse, Andrew M. Lew
Figure 5. In a large animal model (sheep), CTLA4 targeting with hIg as a dimerization moiety and phospholipase D of Corynebacterium pseudotuberculosis is the most effective at protection against challenge. Percentage of the animals protected from challenge by 106 CFU of C. pseudotuberculosis injected just above the coronet. Protection was defined as the animal not having abscesses in any of the following lymph nodes: popliteal, inguinal and prefemoral both left and right.
Molecular subgroup of periodontitis revealed by integrated analysis of the microbiome and metabolome in a cross-sectional observational study
Published in Journal of Oral Microbiology, 2021
Hee Sam Na, Suhkmann Kim, Seonghye Kim, Yeuni Yu, Si Yeong Kim, Hyun-Joo Kim, Ju Youn Lee, Jae-Hyung Lee, Jin Chung
Next, the LEfSe algorithm [20] was used to determine discriminant bacterial species. In buccal samples, among the most significant taxa, Gemella haemolysans, P. gingivalis, Filifactor alocis, Fusobacterium nucleatum, and T. forsythia were more abundant in the PT group than in the H group. The abundance of Haemophilus parainfluenzae, Prevotella melaninogenica, and Corynebacterium pseudotuberculosis was significantly higher in the H group than in the PT group (Figure 3(a,b)). When the PT_G1 and PT_G2 subgroups were compared, significant taxa, including T. denticola and Treponema socranskii, were more abundant in the PT_G2 subgroup (Figure 3(c)). Concerning supragingival plaque samples, Streptococcus sanguinis, Capnocytophaga species (including C. granulosa, C. sputigena, and C. leadbetteri), P. gingivalis, F. alocis, and T. socranskii were significantly more abundant in the PT group than in the H group. In the H group, the abundance of H. parainfluenzae, Rothia dentocariosa, Actinomyces johnsonii, and Kingella oralis was significantly higher than that in the PT group (Figure 3(d,e)). When the PT_G1 and PT_G2 subgroups were compared, the abundance of T. forsythia and Prevotella species that included P. salivae, P. oulurum, P. sacchrolytica, and P. loescheii was significantly higher in the PT_G2 subgroup (Figure 3(f)). The relative abundance of the significant taxa determined by LEfSe was also plotted (Supplementary Figure S1).
Fatal diphtheria myocarditis in a 3-year-old girl—related to late availability and administration of antitoxin?
Published in Paediatrics and International Child Health, 2018
Karlijn Van Damme, Natasja Peeters, Philippe G. Jorens, Tine Boiy, Marjan Deplancke, Hilde Audiens, Marek Wojciechowski, Jozef De Dooy, Margreet te Wierik, Erika Vlieghe
Diphtheria is an acute and fulminant infectious disease caused by toxicogenic strains of corynebacteria, i.e. Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. C. diphtheriae is the most common toxicogenic strain and is associated with person-to-person spread [1–3]. Respiratory diphtheria is usually characterised by a variable degree of pharyngitis followed by the formation of unilateral or bilateral tonsillar pseudomembranes. More severe illness can be associated with inflammation and oedema of the surrounding cervical lymph nodes, causing a bull-neck appearance. When it enters the bloodstream, the highly potent exotoxin may cause serious systemic complications, including myocarditis, which is often fatal, and peripheral neuropathy [1–4].