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The rho Gene Family
Published in Juan Carlos Lacal, Frank McCormick, The ras Superfamily of GTPases, 2017
Rosario Perona, Rafael P. Ballestero, Juan Carlos Lacal
Partial sequencing of rho-GAP revealed significant homology with the product of the ber (breakpoint cluster region) gene, which is an important region involved in the chromosomal translocations present in chronic myeloid leukemias and acute lymphoid leukemias of Philadelphia chromosome positive patients (Figure 3). A bcr-related protein, n-chimerin, also has significant homology with the rho A-GAP peptide.37 Out of 31 amino acids in the rhoA-GAP peptide, ber and n-chimerin show 50 and 43% identity, respectively.38 The carboxyl terminal domains of ber and n-chimerin gene products both have in vitro GAP activity for rac proteins and are members of the rho branch.
The impact of biologic agents on health-related quality of life outcomes in patients with psoriasis
Published in Expert Review of Clinical Immunology, 2018
Jillian Frieder, Dario Kivelevitch, Connie Tran Fiore, Saadeddine Saad, Alan Menter
Chronic systemic inflammation and shared inflammatory pathways between psoriasis and other immune-mediated disorders contribute to the higher prevalence rates of comorbidities among psoriasis patients [12–14]. These include, but are not limited to, psoriatic arthritis (PsA), autoimmune diseases (i.e. Crohn’s disease and ulcerative colitis), cardiovascular disorders, and related risk factors (i.e. obesity, hypertension, diabetes mellitus type 2, and metabolic syndrome), with moderate-to-severe disease associated with an increased all-cause mortality and an estimated 4- to 5-year reduction in life expectancy [12,13,15–22]. One proposed mechanism linking psoriasis and some of these aforementioned comorbidities is adipocyte tissue dysfunction. In response to inflammation, adipose tissue releases specialized proinflammatory adipokines (i.e. leptin, chimerin, and adiponectin), which further drive inflammation and may also have an influence on glucose and lipid metabolism, obesity, and other cardiovascular risk factors. Leptin levels are shown to be elevated in patients with psoriasis and appear to correlate with psoriasis severity and duration [23–26]. Chronic systemic inflammation is also linked to platelet dysregulation, augmented microparticle release, and altered lipoprotein composition, further connecting psoriasis with cardiovascular disease [27–29].