CD78

CD78

Monocyte and lymphocyte membrane markers: Ontogeny and clinical significance

Published in Gabriel Virella, Medical Immunology, 2019

Scott Sugden, Damien Montamat-Sicotte, Karen K. Yam, Joseph Murphy, Bader Yassine Diab, Virginia Litwin

Plasma cells. Long-lived plasma cells are terminally differentiated cells that function to secrete large amounts of immunoglobulins and can persist for years. Most plasma cells home to the bone marrow, and, to a lesser extent, in the spleen, and peripheral tissues. Specialized niches of the BM allow the long-term survival of plasma cells, and the cellular population of plasma cells is hypothesized to be maintained through the continuous, antigen-driven differentiation of memory B cells. Plasma cells typically display a phenotype of CD20−, CD38high, CD27high, CD138+, TACI+ and/or BCMA+, CD126+, CD319+, and CD78+.

Transcriptional regulation of B cell class-switch recombination: the role in development of noninfectious complications

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Journal Information

Published in Expert Review of Clinical Immunology, 2022

Stelios Vlachiotis, Hassan Abolhassani

Optimally, the reentry of GC B cells to the LZ with a high-affinity BCR leads to expanded T cell help, favoring both PI3K/AKT and NF-κB signaling pathways. Strong NF-κB signaling represses Casitas B-lineage lymphoma (CBL) expression and allows for upregulation of IRF4. IRF4 strongly represses BCL-6 and BACH2 expression and leads to the expression of BLIMP1 and X-box-binding protein 1 (XBP-1) required for plasma cell differentiation and expression of CD138, CD78, and a high level of CD27 [25–27].

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Monocyte and lymphocyte membrane markers: Ontogeny and clinical significance

Transcriptional regulation of B cell class-switch recombination: the role in development of noninfectious complications