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Edible Pulses: Part of A Balanced Diet to Manage Cancer
Published in Rohit Dutt, Anil K. Sharma, Raj K. Keservani, Vandana Garg, Promising Drug Molecules of Natural Origin, 2020
Vandana Garg, Kripi Vohra, Harish Dureja
C. arietinum, also known as chickpea, is a nutritional pulse with medicinal properties. It was processed to isolate an antifungal protein, C-25 which also possessed cytotoxic property. It was able to reduce the proliferation of human oral carcinoma cells (half maximal inhibitory concentration; IC50 value: 37.5 μg/mL). Moreover, the protein did not affect the normal human peripheral blood mononuclear cells at a concentration as high as 600 μg/mL (Kumar et al., 2014). Maggi and his colleagues (2012) isolated seven protease inhibitor concentrates (PICs) from chickpeas and other various leguminous seeds to evaluate their effect on the breast (MDA-MB-231) and prostate (PC-3 and LNCaP) cancer cells. The PIC obtained from C. arietinum inhibited the growth of breast cancer and prostate cancer cells at all concentrations tested during the study (Magee et al., 2012).
Therapeutic Medicinal Mushroom (Ganoderma Lucidum): A Review of Bioactive Compounds and their Applications
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Plant- and Marine-Based Phytochemicals for Human Health, 2018
There are several documented scientific studies regarding the antibacterial and antiviral activity of G. lucidum. However, there are only a few investigations on its antifungal activity. Wang et al. (2005) isolated an antifungal protein, Ganodermin from G. lucidum mycelium that inhibited mycelial growth of Botrytis cinerea, Fusarium oxysporum, and Physalospora piricola.162 Heleno et al. (2013) showed the antifungal properties of G. lucidum extract against Trichoderma viride which exceeded that of standard antibiotics.48, 133T. viride causes green mold disease of mushrooms during their cultivation and is also known for producing allergic symptoms, especially in the immune-compromised individuals.
Programmed cell death in human pathogenic fungi – a possible therapeutic target
Published in Expert Opinion on Therapeutic Targets, 2018
Éva Leiter, László Csernoch, István Pócsi
Antifungal proteins are easy to manufacture, some organisms including industrially important fungi like the penicillin-producer P. chrysogenum secretes the antifungal protein PAF abundantly [87]. Large-scale production of antifungal proteins can be carried out by their heterologous expression in yeasts as well [68]. These molecules can also be synthetized and there is also the example of de novo designed antifungal peptides with apoptotic activity [10], namely the D(KLAKLAK)2 peptidomimetic (D enantiomer) which induced programmed cell death via mitochondrial injury in R. oryzae and M. circinelloides [113].
Recent advances and future perspectives in the pharmacological treatment of Candida auris infections
Published in Expert Review of Clinical Pharmacology, 2021
Daniele R. Giacobbe, Laura Magnasco, Chiara Sepulcri, Malgorzata Mikulska, Philipp Koehler, Oliver A. Cornely, Matteo Bassetti
Neosartorya fischeri antifungal protein 2 (NFAP2) is a novel member of small cysteine-rich and cationic antifungal proteins derived from filamentous ascomycetes, showing synergy with fluconazole, echinocandins, or amphotericin B against C. auris biofilms [94].