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Contraception
Published in S Paige Hertweck, Maggie L Dwiggins, Clinical Protocols in Pediatric and Adolescent Gynecology, 2022
The Yuzpe regimenMany combined hormonal contraceptive pills can be used as EC by combining doses, which are then taken 12 hours apart. Doses range from taking 2 to 5 pills at one timeEfficacy is highest if doses are initiated within 72 hours of unprotected sex; however, they may be started up to 120 hours after unprotected sexMost common side effects: Nausea, irregular bleedingSpecific EC doses for different forms of COCPs can be found at https://ec.princeton.edu/questions/dose.html
Enhancing use of emergency contraceptive pills: A systematic review of women’s attitudes, beliefs, knowledge, and experiences in Australia
Published in Health Care for Women International, 2019
Julie Mooney-Somers, Amber Lau, Deborah Bateson, Juliet Richters, Mary Stewart, Kirsten Black, Melissa Nothnagle
ECPs were initially a combination of oral contraceptive pills known as the Yuzpe regimen; this was approximately 75% effective in preventing pregnancy but had unpleasant side effects (Shochet et al., 2004). A single-dose ECP has been available worldwide since the 1990s (Cameron et al., 2017); a 1.5 mg dose of levonorgestrel (LNG) is approximately 85% effective at preventing pregnancy and better tolerated than the Yuzpe regimen (Family Planning NSW, 2013; Shochet et al., 2004). LNG-ECP is licensed for use up to 72 h after unprotected intercourse (World Health Organization, 2012); studies show it may be effective for at least 4 days after unprotected intercourse (International Consortium for Emergency Contraception, 2012; Rossi, 2014). LNG-ECP is safe for repeated use and does not increase the risk of cancer or ectopic pregnancy, or affect future fertility, nor can it harm an existing pregnancy (World Health Organization, 2010). The most recently introduced ECP—ulipristal acetate (UPA), a selective progesterone receptor modulator—became available in Europe in 2009 and the US in 2010; UPA prevents more pregnancies than levonorgestrel and is effective up to 5 days after unprotected intercourse (Glasier, Cameron, et al., 2010). ECPs inhibit or delay ovulation until any present sperm are unable to fertilize, they are ineffective if administered after ovulation has occurred; because ECPs prevent fertilization they are not an abortifacient (Cameron et al., 2017; Eshre Capri Workshop Group et al., 2015).