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Medicinal Plants of China Focusing on Tibet and Surrounding Regions
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Jiangqun Jin, Chunlin Long, Edward J. Kennelly
Chemical constituents: More than 70 compounds have been isolated and identified, including chlorogenic acid (Figure 2.9), and other phenylpropanoids: syringin, 1,3-dicaffeoylquinicacid, 3-caffeoylquinicacid, 1,5-dicaffeoyl-4-succinoylquinicacid, 1,4-dicaffeoylquinicacid; flavonoids: rutin (Figure 2.9) hispidulin, jaceosidin, luteolin, nepetin, apigenin; coumarins: coumarin, osthol, isopimpinellin, bergapten, xanthotoxol, alloisoimperatorin, oroselol; lignans: arctigenin-4-O-(6″-O-acetyl-β-D-glucoside), arctigenin-4-O-(2″-O-acetyl-β-D-glucoside), arctigenin-4-O-(3″-O-acetyl-β-D- glucoside), arctiin, and arctigenin (Chik et al., 2015); steroids: bufotalin, telocinobufagin, gamabufotalin (Zhang et al., 2011), daucosterol, β-sitosterol; sesquiterpenes: sausinlactoneA-(1S,3S,5S,6S,7S,11S)-3-hydroxyl-11; polysaccharides: glucose, galactose, xylose, rhamnose, arabinose, and galacturonic acid; and ceramides (Chik et al., 2015).
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Roots and fruits contain several furocoumarins, e.g., angelicin, bergapten and xanthotoxin, as well as umbelliprenin and various phenols. The main constituent of the root essential oil is beta-phellandrene; others include alpha-pinene, borneol, osthenole, osthole, angelicin, methyl ethyl acetic acid, diacetyl, methanol, ethanol, and furfural. The most important aroma compound is a lactone of 15-hydroxypentadecanoic acid. The flavonoid archange-lenone has recently been identified Escher et al. identified five previously unknown phellandrene derivatives with a typical angelica smell from the root oil: 2-nitro-l,5-P-menthadiene, cis and trans 6-nitro-1(7), 2P menthadiene; trans-1(7)-5P menthadiene-2-yl-acetate, and 7-isopropyl-5-methyl-5-bicyclo(2.2.2.) octan-2-on.86 The seed oil is said to contain 0.5% imperatorin, 0.1% bergaptene, 0.02% xanthotoxol, 0.04% umbelliprenin and a phenol. Phellandrene, methyl ethyl acetic acid, and hydroxymynstic acid are also reported.
Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation
Published in Xenobiotica, 2018
Guiyuan He, Johanna Troberg, Xia Lv, Yang-Liu Xia, Liang-Liang Zhu, Jing Ning, Guang-Bo Ge, Moshe Finel, Ling Yang
Xanthotoxol (8-hydroxypsoralen) is a furanocoumarin which isolated from seeds of Fructus Cnidii (Wei et al., 2004) and roots of Radix Angelicae Dahuricae (Liu et al., 2014). Traditionally, Fructus Cnidii is used to treat impotence, women sterility, ringworm, and other medical problems (Li et al., 2015). The extract of Fructus Cnidii could prevent the ventricular fibrillation that is induced by chloroform. The total coumarin in Fructus Cnidii has bronchial relaxation effect and the methanol extract of Fructus Cnidii also displayed anti-allergic effect (Chen et al., 2006; Matsuda et al., 2002). Xanthotoxol is one of the components of Fructus Cnidii and its biological activities have been investigated. It was reported that xanthotoxol has anti-arrhythmia (Lian et al., 1996), anti-inflammatory (Lian et al., 1998), antioxidation (Ng et al., 2000), antibacterial (Yang et al., 2016), 5-hydroxytryptamine antagonistic (Sethi & Naik, 1979) and neuroprotective effects (He et al., 2013; Sethi et al., 1992). Xanthotoxol also displayed weak inhibitory effect toward β-secretase, which is a potential drug target for Alzheimer’s disease (Marumoto & Miyazawa, 2012).