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Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Bark and leaves contain a pungent volatile oil, the stem yielding 0.56 to 1.13%, leaves up to 4.69%, the chief constituent being umbellulone (40 to 60%), a ketone C30H14O; eugenol, 1-alpha-pinene, cineole, safrole, methyl eugenol, formic acid. Buttery et al.328 found the volatile oil of the leaves to contain 39% umbellulone, 19% 1-8-cineole, 7.6% alpha-terpineol, 6.2% terpinen-4-01, 6% sabinene, 4.7% alpha-pinene, and 5.4% 3,4-dimethoxyallylben-zene. Twenty-six other compounds were characterized. Lawrence193 compares the chemical menus from California Bay, Grecian Bay, and Jamaica Bay, devoting two pages of tables to Umbellularia.
Targeting pituitary adenylate cyclase-activating polypeptide (PACAP) with monoclonal antibodies in migraine prevention: a brief review
Published in Expert Opinion on Investigational Drugs, 2020
Cecilia Rustichelli, Flavia Lo Castro, Carlo Baraldi, Anna Ferrari
The antagonist properties of ALD1910, a monoclonal antibody 4000-fold more selective for PACAP38 and PACAP27 than VIP, were tested in an umbellulone-induced rat model of headache. Umbellulone acts on the TRPA1 receptor, inducing neurogenic vasodilation (clinically evident as an increase in the animal’s facial temperature) and parasympathetic lacrimation. ALD1910 led to a dose-dependent inhibition of umbellulone-induced neurogenic vasodilatation and parasympathetic lacrimation [51]. At last, a first-in-human, randomized, double-blind, and placebo-controlled study in a healthy population is ongoing to determine the safety and tolerability of ALD1910 (NCT04197349).
Neuronal and non-neuronal TRPA1 as therapeutic targets for pain and headache relief
Published in Temperature, 2023
Luigi F. Iannone, Romina Nassini, Riccardo Patacchini, Pierangelo Geppetti, Francesco De Logu
Umbellulone, the major constituent of the Umbellularia californica (California bay laurel), is known to provoke migraine and cluster headache in susceptible individuals [110]. This irritant molecule has been identified as a TRPA1 agonist in vitro and can cause nociceptive behavior, vasodilation in the nasal mucosa, and release of CGRP from meningeal tissue in rats. All in vivo responses evoked by umbellulone were abolished in mice with TRPA1 deletion [110]. The hypothesis that migraine provoking agents, such as chlorine, cigarette smoke, formaldehyde, and others, may act in humans by stimulating TRPA1 is strengthened by these findings.