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Dynamization
Published in Dinesh Kumar Jain, Homeopathy, 2022
According to homeopathy, dilution and trituration increase the potency of a drug. The material part of the medicine is lessened with each degree of dynamization of 50,000 times and yet incredibly increased in power. The 30th thus progressively prepared would give a fraction almost impossible to be expressed in number but highly potent in power.
How classical procedures lost ground
Published in C. P. Khare, Evidence-based Ayurveda, 2019
Thus, impregnating and triturating the herb was of utmost importance in the mind of the physician. It was important to ensure that the herb, as soon as administered, is absorbed quickly at the cell level and enters the body as a dynamic agent.
Nanocarrier Technologies for Enhancing the Solubility and Dissolution Rate of Api
Published in Debarshi Kar Mahapatra, Sanjay Kumar Bharti, Medicinal Chemistry with Pharmaceutical Product Development, 2019
Ashwini Deshpande, Tulshidas S. Patil
The selection of the solidification method will depend upon the oily excipients used in the formulation, and physicochemical properties of therapeutic active and its compatibility with other excipients. Spray drying using suitable carrier, for example, Aerosil 200, silicon dioxide, magnesium stearate [153–155].Physical adsorption by using an inert carrier or adsorbent; e.g., dibasic calcium phosphate, lactose, microcrystalline cellulose, colloidal silicon dioxide and Neusilin [11, 141].Direct trituration by using aeroperl [156].Lyophilization [10].Melt Extrusion/Extrusion Spheronization [10].Melt granulation [10]
Sacubitril-valsartan cocrystal revisited: role of polymer excipients in the formulation
Published in Expert Opinion on Drug Delivery, 2021
Yingxi Zhang, Xiaoxiao Du, Hanxun Wang, Zhonggui He, Hongzhuo Liu
The pharmacokinetic study was carried out in male Sprague-Dawley (SD) rats weighing 230–250 g (n = 6). Diet was prohibited for 12 h before the experiment, while water was taken freely. According to the recommended dosage of consumer available prescriptions (200 mg/times), it is converted into a rat dosage (20.57 mg/kg) [31]. Oral formulation was prepared in suspension (2 ml) form by triturating, accurately weighed amounts of powdered compounds in water with or without pre-dissolution polymers (4 mg/mL). After single oral administration to SD rats, blood was withdrawn at different times and then samples were analyzed by UPLC-MS. All experiments were executed in compliance with Animal Management Rules of the Ministry of Health of the People’s Republic of CN (document number 55, 2001) and the Animal Experiment Ethics Review of Shenyang Pharmaceutical University.
Application of liquisolid technology for promoting the renoprotective efficacy of walnut extracts in chronic renal failure rat model
Published in Drug Development and Industrial Pharmacy, 2019
Sahar Youssef Al-Okbi, Doha Abdou Mohamed, Thanaa El-Sayed Hamed, Sameh Hosam Abd El-Alim, Ahmed Alaa Kassem, Dina Mahmoud Mostafa
The liquisolid formulations were prepared in a three step process as follows; Firstly, a weighed amount of the Wmix was dispersed in the selected nonvolatile solvents to form a liquid medication with two different concentrations, i.e. 25 and 50% w/w. Secondly, the calculated quantity of the carrier material (MCC) was blended with liquid medication in order to achieve an even distribution of the liquid medication into the powder. Mixing took place by trituration using a mortar and a pestle. Finally, the coating material (silicon dioxide) was added and mixed thoroughly in the mortar to produce a dry looking, free flowing powder [33]. Eight liquisolid systems were prepared and their composition is presented in Table 1. For each formulation, the liquid load factor (Lf) was calculated according to Equation (2). The amounts of liquid medication (W) corresponding to 15 mg of the extracts, as well as the carrier (Q) and coating (q) materials, to be introduced in each formulation, were then determined employing Equations (3) and (4).
Optimized methods for rapidly dissecting spinal cords and harvesting spinal motor neurons with high survival and purity from rats at different embryonic stages
Published in The Journal of Spinal Cord Medicine, 2018
Shudong Chen, Ruimin Tian, Hui Li, Meihui Chen, Hu Zhang, Dingkun Lin
During the tissue dissociation, trypsin or panpain digesting technique can be used, but the enzyme concentration and its time must be noted. DNAse was required to avoid DNA wrapping over protein surface during dissociation. Cell viability is greatly influenced by trituration procedure.44 Neurons are too vulnerable and cell loss may be caused during digestion and trituration. Foaming should be avoided during trituration, for cells may be lysed at an air-liquid interface. It thereby needs very gentle trituration by a Gilson blue pipette tip.